{"id":72038,"date":"2026-08-01T07:31:15","date_gmt":"2026-08-01T05:31:15","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/08\/01\/senspots-when-b-cells-age-in-place-qianzhao-ji\/"},"modified":"2026-08-01T07:31:15","modified_gmt":"2026-08-01T05:31:15","slug":"senspots-when-b-cells-age-in-place-qianzhao-ji","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/08\/01\/senspots-when-b-cells-age-in-place-qianzhao-ji\/","title":{"rendered":"SenSpots: when B cells age in place. Qianzhao Ji"},"content":{"rendered":"<div>\n<p><b>Trends Immunol<\/b>. 2026 Aug 1:S1471-4906(26)00187-0. doi: 10.1016\/j.it.2026.07.008. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Spatial multi-omics of aging human lymph nodes by Fan and colleagues reveals that immunosenescence manifests as focal B cell coalescence into &#8216;SenSpots&#8217; within germinal centers, where concerted epigenetic, transcriptional, proteomic, and metabolic reprogramming spatially orchestrates the decline of humoral immunity.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42538165\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=100966032&amp;ff=20260801013115&amp;v=2.20.0.post5+40e1b98\">42538165<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.it.2026.07.008\">10.1016\/j.it.2026.07.008<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Trends Immunol. 2026 Aug 1:S1471-4906(26)00187-0. doi: 10.1016\/j.it.2026.07.008. Online ahead of print. ABSTRACT Spatial multi-omics of aging human lymph nodes by Fan and colleagues reveals that immunosenescence manifests as focal B cell coalescence into &#8216;SenSpots&#8217; within germinal centers, where concerted epigenetic, transcriptional, proteomic, and metabolic reprogramming spatially orchestrates the decline of humoral immunity. PMID:42538165 | DOI:10.1016\/j.it.2026.07.008<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,68],"tags":[],"class_list":["post-72038","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-trends-in-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/72038","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=72038"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/72038\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=72038"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=72038"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=72038"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}