{"id":72039,"date":"2026-08-01T07:31:15","date_gmt":"2026-08-01T05:31:15","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/08\/01\/targeting-the-fate-of-exhausted-cd8-t-cells-daniel-t-utzschneider\/"},"modified":"2026-08-01T07:31:15","modified_gmt":"2026-08-01T05:31:15","slug":"targeting-the-fate-of-exhausted-cd8-t-cells-daniel-t-utzschneider","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/08\/01\/targeting-the-fate-of-exhausted-cd8-t-cells-daniel-t-utzschneider\/","title":{"rendered":"Targeting the fate of exhausted CD8+ T cells. Daniel T Utzschneider"},"content":{"rendered":"<div>\n<p><b>Trends Immunol<\/b>. 2026 Jul 31:S1471-4906(26)00181-X. doi: 10.1016\/j.it.2026.07.002. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>CD8<sup>+<\/sup> T cell exhaustion is increasingly recognized as a regulated adaptation to chronic antigenic stimulation rather than a simple immune failure. Indeed, recent studies reveal that exhaustion is imprinted early after T cell activation, integrating transcriptional and epigenetic cues to balance effector function with long-term persistence. Key regulators, including Inhibitor of DNA binding 3 (ID3), Thymocyte selection high mobility box protein (TOX), MYB, Kr\u00fcppel-like factor 2 (KLF2), and Special AT-rich sequencing binding protein 1 (SATB1), orchestrate this process, preserving stem-like precursor populations that sustain immunity during chronic infection and cancer. This emerging view frames exhaustion as a context-dependent extension of the memory program rather than its collapse. By defining the molecular and functional logic of exhaustion, we highlight how these insights can inform new approaches to manipulate T cell fate for therapeutic benefit.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42538164\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=100966032&amp;ff=20260801013115&amp;v=2.20.0.post5+40e1b98\">42538164<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.it.2026.07.002\">10.1016\/j.it.2026.07.002<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Trends Immunol. 2026 Jul 31:S1471-4906(26)00181-X. doi: 10.1016\/j.it.2026.07.002. Online ahead of print. ABSTRACT CD8+ T cell exhaustion is increasingly recognized as a regulated adaptation to chronic antigenic stimulation rather than a simple immune failure. Indeed, recent studies reveal that exhaustion is imprinted early after T cell activation, integrating transcriptional and epigenetic cues to balance effector function &#8230; <a title=\"Targeting the fate of exhausted CD8+ T cells. Daniel T Utzschneider\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/01\/targeting-the-fate-of-exhausted-cd8-t-cells-daniel-t-utzschneider\/\" aria-label=\"Read more about Targeting the fate of exhausted CD8+ T cells. Daniel T Utzschneider\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,68],"tags":[],"class_list":["post-72039","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-trends-in-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/72039","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=72039"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/72039\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=72039"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=72039"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=72039"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}