{"id":72117,"date":"2026-08-04T01:25:02","date_gmt":"2026-08-03T23:25:02","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/08\/04\/the-pentose-phosphate-pathway-in-immunotherapyrachel-d-loo-on-3-de-august-de-2026-at-1000\/"},"modified":"2026-08-04T01:25:02","modified_gmt":"2026-08-03T23:25:02","slug":"the-pentose-phosphate-pathway-in-immunotherapyrachel-d-loo-on-3-de-august-de-2026-at-1000","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/08\/04\/the-pentose-phosphate-pathway-in-immunotherapyrachel-d-loo-on-3-de-august-de-2026-at-1000\/","title":{"rendered":"The Pentose Phosphate Pathway in Immunotherapy\u200bRachel D Loo   on 3 de August de 2026 at 10:00"},"content":{"rendered":"<div>\n<p><b>J Leukoc Biol<\/b>. 2026 Aug 3:qiag106. doi: 10.1093\/jleuko\/qiag106. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Emerging evidence has highlighted the influence of cellular metabolism on both cancer and T cell growth and survival, including in the context of adoptive cell immunotherapy. It is known that T cells heavily rely on glycolysis for cell proliferation and mediating effector functions. However, less is known about the role of the pentose phosphate pathway (PPP), a parallel metabolic pathway that produces antioxidant and biosynthetic precursors, towards regulating antitumor T cell function. In this review, we summarize the PPP&#8217;s role as a time-dependent regulator of T cell activation and redox balance, and its association with improved functional capacity in exhausted T cells. We further highlight the contrasting role of the PPP for CD8+ and CD4+ T cell differentiation in guiding antitumor responses, as well as a unique connection in the glycogen-PPP axis to CD8+ memory T cells. Finally, we summarize global metabolic regulators that drive expression of PPP enzymes and discuss future avenues for immunotherapy that could take advantage of our current understanding of the PPP&#8217;s role in T cell metabolism.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42546150\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=8405628&amp;ff=20260803192501&amp;v=2.20.0.post5+40e1b98\">42546150<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jleuko\/qiag106\">10.1093\/jleuko\/qiag106<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Leukoc Biol. 2026 Aug 3:qiag106. doi: 10.1093\/jleuko\/qiag106. Online ahead of print. ABSTRACT Emerging evidence has highlighted the influence of cellular metabolism on both cancer and T cell growth and survival, including in the context of adoptive cell immunotherapy. It is known that T cells heavily rely on glycolysis for cell proliferation and mediating effector &#8230; <a title=\"The Pentose Phosphate Pathway in Immunotherapy\u200bRachel D Loo   on 3 de August de 2026 at 10:00\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/04\/the-pentose-phosphate-pathway-in-immunotherapyrachel-d-loo-on-3-de-august-de-2026-at-1000\/\" aria-label=\"Read more about The Pentose Phosphate Pathway in Immunotherapy\u200bRachel D Loo   on 3 de August de 2026 at 10:00\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86,42],"tags":[],"class_list":["post-72117","post","type-post","status-publish","format-standard","hentry","category-journal-of-leukocyte-biology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/72117","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=72117"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/72117\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=72117"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=72117"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=72117"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}