{"id":72405,"date":"2026-08-07T06:32:38","date_gmt":"2026-08-07T04:32:38","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/08\/07\/antigen-presentation-at-the-blood-brain-barrier-amplifies-neuroinflammation-sidar-aydin\/"},"modified":"2026-08-07T06:32:38","modified_gmt":"2026-08-07T04:32:38","slug":"antigen-presentation-at-the-blood-brain-barrier-amplifies-neuroinflammation-sidar-aydin","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/08\/07\/antigen-presentation-at-the-blood-brain-barrier-amplifies-neuroinflammation-sidar-aydin\/","title":{"rendered":"Antigen presentation at the blood-brain barrier amplifies neuroinflammation. Sidar Aydin"},"content":{"rendered":"<div>\n<p><b>Trends Immunol<\/b>. 2026 Aug 7:S1471-4906(26)00185-7. doi: 10.1016\/j.it.2026.07.006. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Immune surveillance of the central nervous system (CNS) is regulated by the brain barriers. Antigen presentation at the blood-brain barrier (BBB) has been proposed to promote antigen-specific T-cell entry into the CNS, largely based on in vitro studies. Recent in vivo and transcriptomic studies call for a reassessment of this concept. In healthy mouse and human CNS endothelium, major histocompatibility complex (MHC) class I expression is low, and MHC class II is minimal to absent. During neuroinflammation, brain microvascular endothelial cells (BMECs) can acquire antigen-presenting features, predominantly in the context of strong or prolonged inflammation. We propose that BMEC antigen presentation amplifies vascular pathology rather than initiating CNS T-cell entry during immune surveillance or disease.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42562740\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=100966032&amp;ff=20260807003238&amp;v=2.20.1\">42562740<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.it.2026.07.006\">10.1016\/j.it.2026.07.006<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Trends Immunol. 2026 Aug 7:S1471-4906(26)00185-7. doi: 10.1016\/j.it.2026.07.006. Online ahead of print. ABSTRACT Immune surveillance of the central nervous system (CNS) is regulated by the brain barriers. Antigen presentation at the blood-brain barrier (BBB) has been proposed to promote antigen-specific T-cell entry into the CNS, largely based on in vitro studies. Recent in vivo and transcriptomic &#8230; <a title=\"Antigen presentation at the blood-brain barrier amplifies neuroinflammation. Sidar Aydin\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/07\/antigen-presentation-at-the-blood-brain-barrier-amplifies-neuroinflammation-sidar-aydin\/\" aria-label=\"Read more about Antigen presentation at the blood-brain barrier amplifies neuroinflammation. Sidar Aydin\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,68],"tags":[],"class_list":["post-72405","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-trends-in-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/72405","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=72405"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/72405\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=72405"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=72405"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=72405"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}