{"id":72614,"date":"2026-08-11T00:50:10","date_gmt":"2026-08-10T22:50:10","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/08\/11\/metabolic-crosstalk-between-c-myc-and-glutamine-utilization-sustains-igm-b-cell-immunity-in-teleosts\/"},"modified":"2026-08-11T00:50:10","modified_gmt":"2026-08-10T22:50:10","slug":"metabolic-crosstalk-between-c-myc-and-glutamine-utilization-sustains-igm-b-cell-immunity-in-teleosts","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/08\/11\/metabolic-crosstalk-between-c-myc-and-glutamine-utilization-sustains-igm-b-cell-immunity-in-teleosts\/","title":{"rendered":"Metabolic crosstalk between c-Myc and glutamine utilization sustains IgM+ B-cell immunity in teleosts"},"content":{"rendered":"<div>\n<p><b>J Immunol<\/b>. 2026 Aug 4;215(8):vkag227. doi: 10.1093\/jimmun\/vkag227.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>B-cell responses rely on a tightly coordinated interplay between transcriptional programs and metabolic reprogramming. Upon activation, B cells remodel their metabolic profiles, with enhanced glutamine metabolism supporting biomass synthesis and proliferation. However, whether and how glutaminolysis underpins B-cell responses in early vertebrates remains largely unexplored. Here, using the Nile tilapia (Oreochromis niloticus) as a model, we demonstrate that IgM+ B cells markedly increase glutamine utilization upon activation. Glutamine deprivation impaired B-cell activation and proliferation, whereas glutamine supplementation promoted these processes. During Edwardsiella piscicida infection, pharmacological inhibition of glutamine metabolism significantly reduced the expansion of IgM+ B cells and compromised antibody secretion. Mechanistically, glutamine metabolism in tilapia IgM+ B cells was governed by the transcription factor c-Myc. Inhibition of c-Myc disrupted glutaminolysis, leading to diminished B-cell proliferation and antibody production. Upon activation, IgM+ B cells coordinated c-Myc expression and downstream glutamine metabolism through the mTORC1 and ERK signaling pathways, thereby coordinating metabolic and immune functions. Notably, this regulatory mechanism operated in a B cell-intrinsic manner and was independent of T-cell help. Collectively, our findings reveal that teleost B cells possess evolutionarily conserved and sophisticated immunometabolic regulatory programs. This study provides new insights into how metabolic pathways are integrated with immune signaling to control B-cell function, highlighting coordinated immunometabolic regulation as a fundamental mechanism underlying vertebrate B-cell immunity.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42574524\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=2985117R&amp;ff=20260810185009&amp;v=2.20.1\">42574524<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jimmun\/vkag227\">10.1093\/jimmun\/vkag227<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Immunol. 2026 Aug 4;215(8):vkag227. doi: 10.1093\/jimmun\/vkag227. ABSTRACT B-cell responses rely on a tightly coordinated interplay between transcriptional programs and metabolic reprogramming. Upon activation, B cells remodel their metabolic profiles, with enhanced glutamine metabolism supporting biomass synthesis and proliferation. However, whether and how glutaminolysis underpins B-cell responses in early vertebrates remains largely unexplored. Here, using &#8230; <a title=\"Metabolic crosstalk between c-Myc and glutamine utilization sustains IgM+ B-cell immunity in teleosts\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/11\/metabolic-crosstalk-between-c-myc-and-glutamine-utilization-sustains-igm-b-cell-immunity-in-teleosts\/\" aria-label=\"Read more about Metabolic crosstalk between c-Myc and glutamine utilization sustains IgM+ B-cell immunity in teleosts\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,71],"tags":[],"class_list":["post-72614","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-the-journal-of-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/72614","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=72614"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/72614\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=72614"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=72614"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=72614"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}