{"id":73619,"date":"2026-08-14T23:46:17","date_gmt":"2026-08-14T21:46:17","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/08\/14\/the-transcription-factor-nf-y-promotes-myeloid-cell-survival-and-protects-from-inflammatory-vascular-diseasecarlos-silvestre-roig-on-14-de-august-de-2026-at-1000\/"},"modified":"2026-08-14T23:46:17","modified_gmt":"2026-08-14T21:46:17","slug":"the-transcription-factor-nf-y-promotes-myeloid-cell-survival-and-protects-from-inflammatory-vascular-diseasecarlos-silvestre-roig-on-14-de-august-de-2026-at-1000","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/08\/14\/the-transcription-factor-nf-y-promotes-myeloid-cell-survival-and-protects-from-inflammatory-vascular-diseasecarlos-silvestre-roig-on-14-de-august-de-2026-at-1000\/","title":{"rendered":"The transcription factor NF-Y promotes myeloid cell survival and protects from inflammatory vascular disease\u200bCarlos Silvestre-Roig   on 14 de August de 2026 at 10:00"},"content":{"rendered":"<div>\n<p><b>J Leukoc Biol<\/b>. 2026 Aug 14:qiag113. doi: 10.1093\/jleuko\/qiag113. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Myeloid cells orchestrate vascular inflammation through transcriptional programs that control their maturation, effector function, and survival. While lineage-determining transcription factors establish myeloid identity, our understanding of the transcriptional regulation of myeloid cell behavior in chronic inflammatory contexts remains limited. Nuclear factor-Y (NF-Y) is a trimeric CCAAT-binding transcription factor that regulates cell proliferation and differentiation and is essential for maintaining stem and progenitor cell fitness. Here, we investigate NF-Y activity in myeloid cell function and survival using integrated single-cell transcriptomics and myeloid-specific deletion of the NF-YA subunit. At RNA level, NF-Y subunit transcripts were detected across myeloid compartments, with NF-YA enriched in proliferative macrophages and immature neutrophils. In mouse atherosclerotic lesions, low NF-YA levels were associated with macrophages exhibiting lipid-handling and phagocytic signatures and with neutrophils displaying a proinflammatory phenotype. NF-Y deficiency impaired neutrophil adhesion and rolling, increased their susceptibility to apoptosis, and promoted activation and lipid accumulation in macrophages. In vivo, myeloid NF-YA deficiency reduced circulating neutrophil counts, increased macrophage and neutrophil apoptosis during acute inflammation, expanded necrotic cores, leading to larger and more unstable atherosclerotic lesions, and aggravated both atherosclerosis and injury-induced neointimal thickening. These findings identify NF-Y as a transcriptional safeguard of myeloid cell survival during inflammatory stress, thereby shaping disease progression and outcomes in vascular disease.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42600095\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=8405628&amp;ff=20260814174617&amp;v=2.20.1\">42600095<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jleuko\/qiag113\">10.1093\/jleuko\/qiag113<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Leukoc Biol. 2026 Aug 14:qiag113. doi: 10.1093\/jleuko\/qiag113. Online ahead of print. ABSTRACT Myeloid cells orchestrate vascular inflammation through transcriptional programs that control their maturation, effector function, and survival. While lineage-determining transcription factors establish myeloid identity, our understanding of the transcriptional regulation of myeloid cell behavior in chronic inflammatory contexts remains limited. Nuclear factor-Y (NF-Y) &#8230; <a title=\"The transcription factor NF-Y promotes myeloid cell survival and protects from inflammatory vascular disease\u200bCarlos Silvestre-Roig   on 14 de August de 2026 at 10:00\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/14\/the-transcription-factor-nf-y-promotes-myeloid-cell-survival-and-protects-from-inflammatory-vascular-diseasecarlos-silvestre-roig-on-14-de-august-de-2026-at-1000\/\" aria-label=\"Read more about The transcription factor NF-Y promotes myeloid cell survival and protects from inflammatory vascular disease\u200bCarlos Silvestre-Roig   on 14 de August de 2026 at 10:00\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86,42],"tags":[],"class_list":["post-73619","post","type-post","status-publish","format-standard","hentry","category-journal-of-leukocyte-biology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/73619","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=73619"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/73619\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=73619"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=73619"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=73619"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}