{"id":73664,"date":"2026-08-15T12:00:00","date_gmt":"2026-08-15T10:00:00","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/08\/15\/elevated-il-10-is-linked-with-the-expansion-of-t-bethighcd21low-b-cells-in-patients-with-common-variable-immunodeficiency\/"},"modified":"2026-08-15T12:00:00","modified_gmt":"2026-08-15T10:00:00","slug":"elevated-il-10-is-linked-with-the-expansion-of-t-bethighcd21low-b-cells-in-patients-with-common-variable-immunodeficiency","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/08\/15\/elevated-il-10-is-linked-with-the-expansion-of-t-bethighcd21low-b-cells-in-patients-with-common-variable-immunodeficiency\/","title":{"rendered":"Elevated IL-10 is Linked With the Expansion of T-bethighCD21low B Cells in Patients With Common Variable Immunodeficiency"},"content":{"rendered":"<div>\n<p><b>J Clin Immunol<\/b>. 2026 Aug 15;46(1):83. doi: 10.1007\/s10875-026-02058-2.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Common variable immunodeficiency (CVID) is frequently complicated by autoimmune and inflammatory manifestations associated with profound immune dysregulation (CVIDc), including expansion of T-bet<sup>high<\/sup>CD21<sup>low<\/sup> B cells (CD21<sup>low<\/sup> B cells). Elevated serum IL-10 levels have repeatedly been reported in CVIDc, yet their relationship to CD21<sup>low<\/sup> B-cell differentiation remains unclear. In this study, we determined a significant correlation between increased serum IL-10 levels and frequency of circulating CD21<sup>low<\/sup> B cells, particularly marked in CVIDc patients. Transcriptomic and protein analyses identified multiple cellular sources of IL-10 in CVID, including monocytes, T cells, and a subset of CD21<sup>low<\/sup> B cells in peripheral blood and inflamed tissues. CD21<sup>low<\/sup> B cells expressed elevated levels of IL-10 receptor subunits and displayed intact IL-10-induced STAT3 signaling, indicating preserved responsiveness to IL-10. Functionally, IL-10 alone neither induced CD21<sup>low<\/sup> B-cell differentiation nor inhibited IFN-\u03b3-driven polarization. However, in vitro differentiation assays showed that IL-10 can substitute for IL-21 during CD40L\/T cell-dependent differentiation of CD21<sup>low<\/sup>-like B cells and promote their survival in vitro. These findings suggest that IL-10 may support the expansion and persistence of CD21<sup>low<\/sup> B cells at inflammatory sites. Collectively, our data identify IL-10 as a component of the inflammatory environment associated with CD21<sup>low<\/sup> B-cell expansion and suggest that IL-10 can functionally replace IL-21 during their differentiation and promote their survival in CVID-associated immune dysregulation.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42603226\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_campaign=journals&amp;utm_content=8102137&amp;ff=20260815180452&amp;v=2.20.1\">42603226<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1007\/s10875-026-02058-2\">10.1007\/s10875-026-02058-2<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Clin Immunol. 2026 Aug 15;46(1):83. doi: 10.1007\/s10875-026-02058-2. ABSTRACT Common variable immunodeficiency (CVID) is frequently complicated by autoimmune and inflammatory manifestations associated with profound immune dysregulation (CVIDc), including expansion of T-bethighCD21low B cells (CD21low B cells). Elevated serum IL-10 levels have repeatedly been reported in CVIDc, yet their relationship to CD21low B-cell differentiation remains unclear. &#8230; <a title=\"Elevated IL-10 is Linked With the Expansion of T-bethighCD21low B Cells in Patients With Common Variable Immunodeficiency\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/15\/elevated-il-10-is-linked-with-the-expansion-of-t-bethighcd21low-b-cells-in-patients-with-common-variable-immunodeficiency\/\" aria-label=\"Read more about Elevated IL-10 is Linked With the Expansion of T-bethighCD21low B Cells in Patients With Common Variable Immunodeficiency\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[69,42],"tags":[],"class_list":["post-73664","post","type-post","status-publish","format-standard","hentry","category-journal-of-clinical-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/73664","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=73664"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/73664\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=73664"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=73664"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=73664"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}