{"id":74013,"date":"2026-08-20T06:01:46","date_gmt":"2026-08-20T04:01:46","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/08\/20\/carm1-an-epigenetic-brake-on-cdc1-mediated-antitumor-immunity-congliang-chen\/"},"modified":"2026-08-20T06:01:46","modified_gmt":"2026-08-20T04:01:46","slug":"carm1-an-epigenetic-brake-on-cdc1-mediated-antitumor-immunity-congliang-chen","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/08\/20\/carm1-an-epigenetic-brake-on-cdc1-mediated-antitumor-immunity-congliang-chen\/","title":{"rendered":"CARM1: an epigenetic brake on cDC1-mediated antitumor immunity. Congliang Chen"},"content":{"rendered":"<div>\n<p><b>Trends Immunol<\/b>. 2026 Aug 19:S1471-4906(26)00215-2. doi: 10.1016\/j.it.2026.08.002. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>The underlying mechanism of tumor microenvironment-induced dysfunction of conventional type 1 dendritic cells (cDC1) remains unclear. Zhang et al. identify transforming growth factor \u03b2-driven coactivator-associated arginine methyltransferase 1 (CARM1) as an epigenetic inhibitor of cDC1 cross-presentation. CARM1 is a cell-intrinsic brake, and its inhibition represents a multi-pronged tumor immunotherapy strategy.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42618461\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=100966032&amp;ff=20260820000145&amp;v=2.20.1\">42618461<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.it.2026.08.002\">10.1016\/j.it.2026.08.002<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Trends Immunol. 2026 Aug 19:S1471-4906(26)00215-2. doi: 10.1016\/j.it.2026.08.002. Online ahead of print. ABSTRACT The underlying mechanism of tumor microenvironment-induced dysfunction of conventional type 1 dendritic cells (cDC1) remains unclear. Zhang et al. identify transforming growth factor \u03b2-driven coactivator-associated arginine methyltransferase 1 (CARM1) as an epigenetic inhibitor of cDC1 cross-presentation. CARM1 is a cell-intrinsic brake, and its &#8230; <a title=\"CARM1: an epigenetic brake on cDC1-mediated antitumor immunity. Congliang Chen\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/20\/carm1-an-epigenetic-brake-on-cdc1-mediated-antitumor-immunity-congliang-chen\/\" aria-label=\"Read more about CARM1: an epigenetic brake on cDC1-mediated antitumor immunity. Congliang Chen\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,68],"tags":[],"class_list":["post-74013","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-trends-in-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/74013","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=74013"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/74013\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=74013"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=74013"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=74013"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}