{"id":74416,"date":"2026-08-25T11:16:28","date_gmt":"2026-08-25T09:16:28","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/08\/25\/the-glucose-transporter-glut3-controls-regulatory-t-cell-function-valuekatrin-sinning-miriam-eckstein-xiufeng-zhao-alexandra-freitag-mathias-rosenfeldt-sophia-m-hochrein-martin\/"},"modified":"2026-08-25T11:16:28","modified_gmt":"2026-08-25T09:16:28","slug":"the-glucose-transporter-glut3-controls-regulatory-t-cell-function-valuekatrin-sinning-miriam-eckstein-xiufeng-zhao-alexandra-freitag-mathias-rosenfeldt-sophia-m-hochrein-martin","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/08\/25\/the-glucose-transporter-glut3-controls-regulatory-t-cell-function-valuekatrin-sinning-miriam-eckstein-xiufeng-zhao-alexandra-freitag-mathias-rosenfeldt-sophia-m-hochrein-martin\/","title":{"rendered":"The Glucose Transporter GLUT3 Controls Regulatory T Cell Function. [[{&#8220;value&#8221;:&#8221;Katrin Sinning, \nMiriam Eckstein, \nXiufeng Zhao, \nAlexandra Freitag, \nMathias Rosenfeldt, \nSophia M. Hochrein, \nMartin Vaeth&#8221;}]]"},"content":{"rendered":"<p><img decoding=\"async\" src=\"https:\/\/onlinelibrary.wiley.com\/cms\/asset\/90b1b5f3-61d3-4d08-adf3-49d351b5bee2\/eji70272-gra-0001-m.png\" alt=\"The Glucose Transporter GLUT3 Controls Regulatory T Cell Function\" \/><\/p>\n<p>GLUT3 is essential for T regulatory (Treg) cell metabolic fitness, supporting both glycolysis and mitochondrial function required for their suppressive activity and effector differentiation. Loss of GLUT3 in Treg cells leads to impaired immune regulation and systemic autoimmunity, highlighting a critical role for glucose uptake in maintaining immune tolerance.<\/p>\n<p><\/p>\n<h2>ABSTRACT<\/h2>\n<p>Regulatory T (Treg) cells are central mediators of immune tolerance and are generally considered to rely predominantly on mitochondrial metabolism rather than glucose-driven glycolysis. To define the role of glucose metabolism in Treg cells, we investigated the contribution of the hexose transporters GLUT1 and GLUT3. Genetic ablation of GLUT1 in T cells or selectively in Treg cells had minimal impact on Treg cell numbers, phenotype, or immune homeostasis, indicating that GLUT1 is largely dispensable in this lineage. By contrast, deletion of GLUT3 in T cells resulted in a marked reduction in Treg cell numbers. However, it remained unclear whether this reduction reflected diminished IL-2 production by GLUT3-deficient conventional T cells or a cell-intrinsic requirement for GLUT3 in Treg cells. To investigate this, we generated mice with Treg cell-specific deletion of GLUT3. These animals developed severe systemic inflammation accompanied by lethal cellular and humoral autoimmunity. Mechanistically, GLUT3-deficient Treg cells exhibited reduced glycolytic activity and mitochondrial respiration, leading to impaired suppressive function and defective effector and follicular Treg cell differentiation. Collectively, our findings demonstrate a nonredundant requirement for GLUT3 in Treg cell metabolic fitness and immune regulation, refining the prevailing view that Treg cells operate largely independently of glucose metabolism. Our data further suggest that therapeutic strategies targeting glucose uptake and glycolysis in autoimmune and inflammatory diseases should account for potential adverse effects on Treg cell-mediated immune tolerance.<\/p>","protected":false},"excerpt":{"rendered":"<p>GLUT3 is essential for T regulatory (Treg) cell metabolic fitness, supporting both glycolysis and mitochondrial function required for their suppressive activity and effector differentiation. Loss of GLUT3 in Treg cells leads to impaired immune regulation and systemic autoimmunity, highlighting a critical role for glucose uptake in maintaining immune tolerance. ABSTRACT Regulatory T (Treg) cells are &#8230; <a title=\"The Glucose Transporter GLUT3 Controls Regulatory T Cell Function. [[{&#8220;value&#8221;:&#8221;Katrin Sinning, \nMiriam Eckstein, \nXiufeng Zhao, \nAlexandra Freitag, \nMathias Rosenfeldt, \nSophia M. Hochrein, \nMartin Vaeth&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/25\/the-glucose-transporter-glut3-controls-regulatory-t-cell-function-valuekatrin-sinning-miriam-eckstein-xiufeng-zhao-alexandra-freitag-mathias-rosenfeldt-sophia-m-hochrein-martin\/\" aria-label=\"Read more about The Glucose Transporter GLUT3 Controls Regulatory T Cell Function. [[{&#8220;value&#8221;:&#8221;Katrin Sinning, \nMiriam Eckstein, \nXiufeng Zhao, \nAlexandra Freitag, \nMathias Rosenfeldt, \nSophia M. Hochrein, \nMartin Vaeth&#8221;}]]\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[112,42],"tags":[],"class_list":["post-74416","post","type-post","status-publish","format-standard","hentry","category-european-journal-of-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/74416","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=74416"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/74416\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=74416"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=74416"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=74416"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}