{"id":74624,"date":"2026-08-26T23:53:07","date_gmt":"2026-08-26T21:53:07","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/08\/26\/zinc-finger-protein-600-is-essential-for-the-cytotoxic-function-of-esophageal-cancer-associated-natural-killer-cellsjiongming-he-on-26-de-august-de-2026-at-1000\/"},"modified":"2026-08-26T23:53:07","modified_gmt":"2026-08-26T21:53:07","slug":"zinc-finger-protein-600-is-essential-for-the-cytotoxic-function-of-esophageal-cancer-associated-natural-killer-cellsjiongming-he-on-26-de-august-de-2026-at-1000","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/08\/26\/zinc-finger-protein-600-is-essential-for-the-cytotoxic-function-of-esophageal-cancer-associated-natural-killer-cellsjiongming-he-on-26-de-august-de-2026-at-1000\/","title":{"rendered":"Zinc finger protein 600 is essential for the cytotoxic function of esophageal cancer-associated natural killer cells\u200bJiongming He   on 26 de August de 2026 at 10:00"},"content":{"rendered":"<div>\n<p><b>J Leukoc Biol<\/b>. 2026 Aug 26:qiag119. doi: 10.1093\/jleuko\/qiag119. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Natural killer (NK) cells are active tumoricidal cells that inhibit esophageal cancer (EC) development, making them a prospective immunotherapeutic tool. Nonetheless, NK cells undergo both activation and exhaustion in the tumor microenvironment, but the related mechanisms have not been thoroughly understood. Using a chemical-induced EC model, we investigated the expression pattern and functional properties of zinc finger protein 600 (ZNF600) in EC-associated NK cells. For the first time, we revealed that ZNF600 expression was diminished in EC-associated NK cells, particularly those exhibiting the exhaustion phenotype. In vitro silencing of ZNF600 resulted in a remarkable downregulation of tumor necrosis factor (TNF), interferon-gamma (IFN-\u03b3), and cytolytic perforin and granzyme B, leading to an impairment of NK cell tumoricidal capacity. On the contrary, ZNF600 overexpression promoted NK cell tumoricidal capacity. Adoptive transfer of ZNF600-overexpressing NK cells significantly inhibited the growth of EC implants. Furthermore, EC cells significantly down-regulated ZNF600 in NK cells. Interestingly, neutralizing carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) and T cell immunoglobulin and mucin-domain containing-3 (TIM-3) partially restored ZNF600 expression after co-culture with EC cells. Conclusively, the CEACAM1-TIM-3 signaling axis might decrease ZNF600 in EC-associated NK cells and subsequently suppress NK cell-mediated killing of EC cells. This research discovers a novel mechanism by which the EC microenvironment induces NK cell dysfunction.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42647748\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=8405628&amp;ff=20260826175307&amp;v=2.20.1\">42647748<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jleuko\/qiag119\">10.1093\/jleuko\/qiag119<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Leukoc Biol. 2026 Aug 26:qiag119. doi: 10.1093\/jleuko\/qiag119. Online ahead of print. ABSTRACT Natural killer (NK) cells are active tumoricidal cells that inhibit esophageal cancer (EC) development, making them a prospective immunotherapeutic tool. Nonetheless, NK cells undergo both activation and exhaustion in the tumor microenvironment, but the related mechanisms have not been thoroughly understood. Using &#8230; <a title=\"Zinc finger protein 600 is essential for the cytotoxic function of esophageal cancer-associated natural killer cells\u200bJiongming He   on 26 de August de 2026 at 10:00\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/26\/zinc-finger-protein-600-is-essential-for-the-cytotoxic-function-of-esophageal-cancer-associated-natural-killer-cellsjiongming-he-on-26-de-august-de-2026-at-1000\/\" aria-label=\"Read more about Zinc finger protein 600 is essential for the cytotoxic function of esophageal cancer-associated natural killer cells\u200bJiongming He   on 26 de August de 2026 at 10:00\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86,42],"tags":[],"class_list":["post-74624","post","type-post","status-publish","format-standard","hentry","category-journal-of-leukocyte-biology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/74624","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=74624"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/74624\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=74624"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=74624"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=74624"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}