{"id":75318,"date":"2026-09-04T23:50:03","date_gmt":"2026-09-04T21:50:03","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/09\/04\/the-modular-car-adapting-t-cells-without-reengineering-them\/"},"modified":"2026-09-04T23:50:03","modified_gmt":"2026-09-04T21:50:03","slug":"the-modular-car-adapting-t-cells-without-reengineering-them","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/09\/04\/the-modular-car-adapting-t-cells-without-reengineering-them\/","title":{"rendered":"The Modular CAR: Adapting T Cells without Reengineering Them"},"content":{"rendered":"<div>\n<p><b>Cancer Immunol Res<\/b>. 2026 Sep 4:OF1-OF2. doi: 10.1158\/2326-6066.CIR-26-0906. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>The therapeutic potential of chimeric antigen receptor (CAR) T cells has long been limited by the static nature of the engineered receptor; once manufactured, the cell is committed to a single antigen, unable to respond to the immune evasion and antigen heterogeneity that define solid tumors. Although solutions such as bispecific constructs and logic-gated circuits have been proposed, each encodes additional complexity into the cell product at the time of manufacture, with no capacity for post-infusion reprogramming. In this issue, Kuo and colleagues report a fundamentally different strategy-the meditope-enabled CAR-in which a small, structurally orthogonal peptide-docking interface is embedded into the extracellular domain of the CAR, converting a fixed cellular product into a programmable platform that can be redirected, selectively expanded, or precisely tracked by administering a modular adapter molecule. See related article by Kuo et al., p. XX.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42695598\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=101614637&amp;ff=20260904175003&amp;v=2.20.1\">42695598<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1158\/2326-6066.CIR-26-0906\">10.1158\/2326-6066.CIR-26-0906<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Cancer Immunol Res. 2026 Sep 4:OF1-OF2. doi: 10.1158\/2326-6066.CIR-26-0906. Online ahead of print. ABSTRACT The therapeutic potential of chimeric antigen receptor (CAR) T cells has long been limited by the static nature of the engineered receptor; once manufactured, the cell is committed to a single antigen, unable to respond to the immune evasion and antigen heterogeneity &#8230; <a title=\"The Modular CAR: Adapting T Cells without Reengineering Them\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/09\/04\/the-modular-car-adapting-t-cells-without-reengineering-them\/\" aria-label=\"Read more about The Modular CAR: Adapting T Cells without Reengineering Them\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[55,42],"tags":[],"class_list":["post-75318","post","type-post","status-publish","format-standard","hentry","category-cancer-immunology-reserch","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/75318","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=75318"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/75318\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=75318"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=75318"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=75318"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}