{"id":75757,"date":"2026-09-09T05:43:32","date_gmt":"2026-09-09T03:43:32","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/09\/09\/estrogen-receptor-beta-limits-t-cell-mediated-inflammation-to-maintain-immune-homeostasis\/"},"modified":"2026-09-09T05:43:32","modified_gmt":"2026-09-09T03:43:32","slug":"estrogen-receptor-beta-limits-t-cell-mediated-inflammation-to-maintain-immune-homeostasis","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/09\/09\/estrogen-receptor-beta-limits-t-cell-mediated-inflammation-to-maintain-immune-homeostasis\/","title":{"rendered":"Estrogen receptor beta limits T cell-mediated inflammation to maintain immune homeostasis"},"content":{"rendered":"<div>\n<p><b>J Immunol<\/b>. 2026 Aug 29;215(9):vkag238. doi: 10.1093\/jimmun\/vkag238.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Many autoimmune diseases exhibit a female sex bias in prevalence and severity, yet the mechanisms for this remain unclear. 17\u03b2-estradiol (E2) is a steroid sex hormone with established immunomodulatory roles in CD4+ T cells, which express the nuclear estrogen receptors ER\u03b1 and ER\u03b2. Autoimmune disease patients exhibit reductions in ER\u03b2 expression, suggesting that dysregulated E2 signaling contributes to inflammation. We previously identified a novel role for ER\u03b2 in promoting the TGF-\u03b2-dependent differentiation of Foxp3+ Tregs, supporting the idea that ER\u03b2 has anti-inflammatory functions. In this study, we investigated the functional role of ER\u03b2 in effector T cells, which drive pathogenesis of many autoimmune diseases. CD4+ T cells isolated from mice globally deficient in ER\u03b2 (ER\u03b2-KO) showed enhanced proliferation and polarization to Th1 and Th17 populations ex vivo and conferred more severe inflammation and experimental colitis when transferred to immunodeficient Rag-KO mice. Treatment of ER\u03b2-KO T cells ex vivo with anti-CD3\/28 and PMA\/ionomycin resulted in robust activation-induced production of Th17-associated cytokines, suggesting that ER\u03b2 normally functions to restrain Th17. Collectively, our data support a model in which reduced ER\u03b2 expression may contribute to loss of immunoregulatory signaling and enhanced T cell-driven inflammation.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42710864\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=2985117R&amp;ff=20260908234331&amp;v=2.20.1\">42710864<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jimmun\/vkag238\">10.1093\/jimmun\/vkag238<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Immunol. 2026 Aug 29;215(9):vkag238. doi: 10.1093\/jimmun\/vkag238. ABSTRACT Many autoimmune diseases exhibit a female sex bias in prevalence and severity, yet the mechanisms for this remain unclear. 17\u03b2-estradiol (E2) is a steroid sex hormone with established immunomodulatory roles in CD4+ T cells, which express the nuclear estrogen receptors ER\u03b1 and ER\u03b2. Autoimmune disease patients exhibit &#8230; <a title=\"Estrogen receptor beta limits T cell-mediated inflammation to maintain immune homeostasis\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/09\/09\/estrogen-receptor-beta-limits-t-cell-mediated-inflammation-to-maintain-immune-homeostasis\/\" aria-label=\"Read more about Estrogen receptor beta limits T cell-mediated inflammation to maintain immune homeostasis\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,71],"tags":[],"class_list":["post-75757","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-the-journal-of-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/75757","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=75757"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/75757\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=75757"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=75757"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=75757"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}