{"id":76520,"date":"2026-09-15T17:56:50","date_gmt":"2026-09-15T15:56:50","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/09\/15\/arid2-regulates-peripheral-b-cell-maturation-and-germinal-center-responses-in-vivo\/"},"modified":"2026-09-15T17:56:50","modified_gmt":"2026-09-15T15:56:50","slug":"arid2-regulates-peripheral-b-cell-maturation-and-germinal-center-responses-in-vivo","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/09\/15\/arid2-regulates-peripheral-b-cell-maturation-and-germinal-center-responses-in-vivo\/","title":{"rendered":"Arid2 regulates peripheral B cell maturation and germinal-center responses in vivo"},"content":{"rendered":"<div>\n<p><b>J Immunol<\/b>. 2026 Aug 29;215(9):vkag247. doi: 10.1093\/jimmun\/vkag247.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>SWI\/SNF chromatin remodeling complexes regulate gene expression during development and differentiation. These complexes exist in distinct forms, including the polybromo-associated BAF (PBAF) complex, defined by the ARID2 subunit. ARID2 is frequently mutated in B cell leukemias, but its role in normal B cell development remains unknown. Using Mb1-Cre and CD19-Cre conditional mouse models, we show that Arid2 is required for normal peripheral B-cell maturation. Early deletion with Mb1-Cre caused marked reductions in splenic T1 and T2 transitional B cells, follicular B cells, and recirculating B cells, whereas later deletion with CD19-Cre produced a milder follicular B cell phenotype but a similar reduction in transitional B cells. Bone-marrow progenitor and immature B cell populations were largely preserved, suggesting that the developmental defect emerges during peripheral transitional maturation and follicular B cell differentiation. Transcriptomic profiling of isolated pro-B, pre-B, and follicular B cells revealed that Arid2 loss caused progressive, stage-specific transcriptional dysregulation, including altered AP-1-associated programs and reduced B cell receptor-associated signaling in pre-B and follicular B cells. Functionally, mice with Mb1-Cre-mediated Arid2 deletion mice formed smaller germinal center B cell populations after immunization but maintained total and antigen-specific IgG responses and exhibited increased IgM responses. Together, these findings establish an important role for Arid2 in peripheral B cell maturation and germinal center responses.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42742565\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=2985117R&amp;ff=20260915115649&amp;v=2.20.1\">42742565<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jimmun\/vkag247\">10.1093\/jimmun\/vkag247<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Immunol. 2026 Aug 29;215(9):vkag247. doi: 10.1093\/jimmun\/vkag247. ABSTRACT SWI\/SNF chromatin remodeling complexes regulate gene expression during development and differentiation. These complexes exist in distinct forms, including the polybromo-associated BAF (PBAF) complex, defined by the ARID2 subunit. ARID2 is frequently mutated in B cell leukemias, but its role in normal B cell development remains unknown. Using &#8230; <a title=\"Arid2 regulates peripheral B cell maturation and germinal-center responses in vivo\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/09\/15\/arid2-regulates-peripheral-b-cell-maturation-and-germinal-center-responses-in-vivo\/\" aria-label=\"Read more about Arid2 regulates peripheral B cell maturation and germinal-center responses in vivo\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,71],"tags":[],"class_list":["post-76520","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-the-journal-of-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/76520","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=76520"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/76520\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=76520"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=76520"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=76520"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}