{"id":76627,"date":"2026-09-17T06:27:55","date_gmt":"2026-09-17T04:27:55","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/09\/17\/erythropoietin-impacts-immune-adaptation-through-myeloid-cell-programming-xiangyue-zhang\/"},"modified":"2026-09-17T06:27:55","modified_gmt":"2026-09-17T04:27:55","slug":"erythropoietin-impacts-immune-adaptation-through-myeloid-cell-programming-xiangyue-zhang","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/09\/17\/erythropoietin-impacts-immune-adaptation-through-myeloid-cell-programming-xiangyue-zhang\/","title":{"rendered":"Erythropoietin impacts immune adaptation through myeloid-cell programming. Xiangyue Zhang"},"content":{"rendered":"<div>\n<p><b>Trends Immunol<\/b>. 2026 Sep 16:S1471-4906(26)00230-9. doi: 10.1016\/j.it.2026.08.014. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>The immune system balances protective immunity against pathogens with tolerance to self and selected foreign antigens. Emerging evidence identifies erythropoietin (EPO) as a systemic immunoregulatory signal that links physiological stress to immune adaptation. Beyond its canonical role in erythropoiesis, EPO-EPO receptor (EPOR) signaling reprograms specialized myeloid cells, including macrophages and type 1 conventional dendritic cells (cDC1s), promoting efferocytosis, inflammatory restraint, and maturation-associated cDC1 fate. Through these mechanisms, EPO shapes antigen-specific T-cell responses across transplantation and cancer. We propose that the EPO-EPOR axis functions as a systemic regulator of immune adaptation through myeloid-cellprogramming.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42749579\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=100966032&amp;ff=20260917002754&amp;v=2.20.1\">42749579<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.it.2026.08.014\">10.1016\/j.it.2026.08.014<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Trends Immunol. 2026 Sep 16:S1471-4906(26)00230-9. doi: 10.1016\/j.it.2026.08.014. Online ahead of print. ABSTRACT The immune system balances protective immunity against pathogens with tolerance to self and selected foreign antigens. Emerging evidence identifies erythropoietin (EPO) as a systemic immunoregulatory signal that links physiological stress to immune adaptation. Beyond its canonical role in erythropoiesis, EPO-EPO receptor (EPOR) signaling &#8230; <a title=\"Erythropoietin impacts immune adaptation through myeloid-cell programming. Xiangyue Zhang\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/09\/17\/erythropoietin-impacts-immune-adaptation-through-myeloid-cell-programming-xiangyue-zhang\/\" aria-label=\"Read more about Erythropoietin impacts immune adaptation through myeloid-cell programming. Xiangyue Zhang\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,68],"tags":[],"class_list":["post-76627","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-trends-in-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/76627","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=76627"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/76627\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=76627"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=76627"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=76627"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}