{"id":77279,"date":"2026-09-26T00:16:55","date_gmt":"2026-09-25T22:16:55","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/09\/26\/distinct-effects-of-two-different-human-interferon-alpha-subtypes-on-indicators-of-t-cell-proliferation-activation-and-inhibition\/"},"modified":"2026-09-26T00:16:55","modified_gmt":"2026-09-25T22:16:55","slug":"distinct-effects-of-two-different-human-interferon-alpha-subtypes-on-indicators-of-t-cell-proliferation-activation-and-inhibition","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/09\/26\/distinct-effects-of-two-different-human-interferon-alpha-subtypes-on-indicators-of-t-cell-proliferation-activation-and-inhibition\/","title":{"rendered":"Distinct effects of two different human interferon-alpha subtypes on indicators of T-cell proliferation, activation and inhibition"},"content":{"rendered":"<div>\n<p><b>J Immunol<\/b>. 2026 Aug 29;215(9):vkag259. doi: 10.1093\/jimmun\/vkag259.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Humans produce 12 distinct interferon alpha (IFN-\u03b1) subtypes that were previously thought to be functionally redundant. Recent studies have revealed that IFN-\u03b1 subtypes differ in their ability to control different viral infections. However, little is known about how IFN-\u03b1 subtypes differentially modulate immune cells to mediate these effects. This study compared the effects of IFN-\u03b12 and IFN-\u03b114, subtypes identified to differentially control viral infection, on T cells both in vivo in humanized TKO-BLT mice and in vitro using human peripheral blood mononuclear cells (PBMC). Treatment of humanized mice with the 2 IFN-\u03b1 subtypes resulted in the differential modulation of genes associated with T-cell immunity, such as proliferation, activation and inhibition. Therefore, we assessed whether stimulation of PBMC in the presence of IFN-\u03b12 or IFN-\u03b114 resulted in subtype-specific effects on T cells in vitro. IFN-\u03b114 decreased the proliferation of human CD4+ and CD8+ T cells significantly more than IFN-\u03b12. Additionally, IFN-\u03b114 increased expression of T-cell activation markers and the frequency of IL-2 producing T cells to a significantly greater extent compared to IFN-\u03b12. However, the co-culture of CD8+ T cells with IFN-\u03b1-treated, autologous CD4+ T cells or IFN-\u03b1-matured monocyte-derived dendritic cells (mo-DC) only increased the expression of CD38 compared to no IFN-\u03b1 treatment in a non-subtype specific manner. Overall, we identified IFN-\u03b1 subtype-specific effects on the proliferation and activation of T cells. However, there were no significant differences detected directly between the IFN-\u03b1 subtypes when the effects on CD8+ T cells arose through IFN-\u03b1 pre-treatment of CD4+ T cells or mo-DC.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42789737\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=2985117R&amp;ff=20260925181654&amp;v=2.20.1\">42789737<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jimmun\/vkag259\">10.1093\/jimmun\/vkag259<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Immunol. 2026 Aug 29;215(9):vkag259. doi: 10.1093\/jimmun\/vkag259. ABSTRACT Humans produce 12 distinct interferon alpha (IFN-\u03b1) subtypes that were previously thought to be functionally redundant. Recent studies have revealed that IFN-\u03b1 subtypes differ in their ability to control different viral infections. However, little is known about how IFN-\u03b1 subtypes differentially modulate immune cells to mediate these &#8230; <a title=\"Distinct effects of two different human interferon-alpha subtypes on indicators of T-cell proliferation, activation and inhibition\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/09\/26\/distinct-effects-of-two-different-human-interferon-alpha-subtypes-on-indicators-of-t-cell-proliferation-activation-and-inhibition\/\" aria-label=\"Read more about Distinct effects of two different human interferon-alpha subtypes on indicators of T-cell proliferation, activation and inhibition\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,71],"tags":[],"class_list":["post-77279","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-the-journal-of-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/77279","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=77279"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/77279\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=77279"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=77279"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=77279"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}