{"id":77788,"date":"2026-10-02T06:11:55","date_gmt":"2026-10-02T04:11:55","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/10\/02\/cth522-caf01-vaccination-elicits-clonally-related-th17-subsets-that-mediate-il-17a-dependent-protection-against-chlamydia-trachomatis\/"},"modified":"2026-10-02T06:11:55","modified_gmt":"2026-10-02T04:11:55","slug":"cth522-caf01-vaccination-elicits-clonally-related-th17-subsets-that-mediate-il-17a-dependent-protection-against-chlamydia-trachomatis","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/10\/02\/cth522-caf01-vaccination-elicits-clonally-related-th17-subsets-that-mediate-il-17a-dependent-protection-against-chlamydia-trachomatis\/","title":{"rendered":"CTH522\/CAF01 vaccination elicits clonally related Th17 subsets that mediate IL-17A-dependent protection against Chlamydia trachomatis"},"content":{"rendered":"<div>\n<p><b>J Immunol<\/b>. 2026 Oct 1;215(10):vkag265. doi: 10.1093\/jimmun\/vkag265.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Chlamydia trachomatis is the leading bacterial sexually transmitted pathogen worldwide and a major cause of reproductive tract disease, highlighting the need for an effective vaccine. Defining the immune mechanisms underlying vaccine-induced protection is therefore critical. We previously demonstrated that in mice vaccinated with CTH522\/CAF01, genital tract Th17 cells correlated with protection against both infection and pathology. In this study, we further characterized these vaccine-induced Th17 cells in an infected genital tract. Fate-mapping and single-cell transcriptomic analyses revealed that CTH522\/CAF01 vaccination generated multiple Th17-derived subsets, including a large memory-like population as well as effector Th17 and Th17-derived Th1-like subsets. These subsets shared common TCR clonotypes, and RNA velocity analyses predicted a unified differentiation trajectory, with one precursor population seeding both effector lineages. Our findings demonstrate a high degree of plasticity within the Th17 population and reveals previously uncharacterized Th17 subsets present during infection with C. trachomatis. Functional studies demonstrated that the Th17 subset that produced IL-17A was essential for early bacterial control, whereas IFN-\u03b3-producing Th1 cells and Th17-derived Th1-like cells were not. Collectively, our findings provide mechanistic insight into Th17 biology and redefine the importance of IL-17A producing Th17 cells in early vaccine-mediated protection against C. trachomatis.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42823065\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=2985117R&amp;ff=20261002001154&amp;v=2.20.1\">42823065<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jimmun\/vkag265\">10.1093\/jimmun\/vkag265<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Immunol. 2026 Oct 1;215(10):vkag265. doi: 10.1093\/jimmun\/vkag265. ABSTRACT Chlamydia trachomatis is the leading bacterial sexually transmitted pathogen worldwide and a major cause of reproductive tract disease, highlighting the need for an effective vaccine. Defining the immune mechanisms underlying vaccine-induced protection is therefore critical. We previously demonstrated that in mice vaccinated with CTH522\/CAF01, genital tract Th17 &#8230; <a title=\"CTH522\/CAF01 vaccination elicits clonally related Th17 subsets that mediate IL-17A-dependent protection against Chlamydia trachomatis\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/10\/02\/cth522-caf01-vaccination-elicits-clonally-related-th17-subsets-that-mediate-il-17a-dependent-protection-against-chlamydia-trachomatis\/\" aria-label=\"Read more about CTH522\/CAF01 vaccination elicits clonally related Th17 subsets that mediate IL-17A-dependent protection against Chlamydia trachomatis\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,71],"tags":[],"class_list":["post-77788","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-the-journal-of-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/77788","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=77788"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/77788\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=77788"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=77788"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=77788"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}