{"id":79395,"date":"2026-10-15T10:40:57","date_gmt":"2026-10-15T08:40:57","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/10\/15\/inducible-camp-early-repressor-limits-glycolytic-programming-in-regulatory-t-cells-and-supports-control-of-inflammatory-colitis-valuealeksandra-lopez-krol-luana-silva-daniele-c-nascime\/"},"modified":"2026-10-15T10:40:57","modified_gmt":"2026-10-15T08:40:57","slug":"inducible-camp-early-repressor-limits-glycolytic-programming-in-regulatory-t-cells-and-supports-control-of-inflammatory-colitis-valuealeksandra-lopez-krol-luana-silva-daniele-c-nascime","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/10\/15\/inducible-camp-early-repressor-limits-glycolytic-programming-in-regulatory-t-cells-and-supports-control-of-inflammatory-colitis-valuealeksandra-lopez-krol-luana-silva-daniele-c-nascime\/","title":{"rendered":"Inducible cAMP Early Repressor Limits Glycolytic Programming in Regulatory T Cells and Supports Control of Inflammatory Colitis. [[{&#8220;value&#8221;:&#8221;Aleksandra Lopez Krol, \nLuana Silva, \nDaniele C. Nascimento, \nSophie M. Oberwalder, \nHitikk Chawla, \nGabriel Alberto Barbosa de Carvalho, \nFatima Boukhallouk, \nMonica Romero, \nAnne Hausen, \nMatthias M. Gaida, \nLuciana Berod, \nJos\u00e9 Carlos Alves\u2010Filho, \nTim Sparwasser&#8221;}]]"},"content":{"rendered":"<p><img decoding=\"async\" src=\"https:\/\/onlinelibrary.wiley.com\/cms\/asset\/7ea1665d-2a55-4a61-8f1f-418fad73a0bf\/eji70297-gra-0001-m.png\" alt=\"Inducible cAMP Early Repressor Limits Glycolytic Programming in Regulatory T Cells and Supports Control of Inflammatory Colitis\" \/><\/p>\n<p>This study is focussed on the role of cAMP-dependent transcriptional repressor ICER in regulatory T cell function. Using a conditional knockout model, Treg development, suppressive function, stability, and metabolic phenotype were examined to gain further understanding of the role of cAMP-dependent signalling in regulatory T cells. <\/p>\n<p><\/p>\n<h2>ABSTRACT<\/h2>\n<p>Regulatory T cells (Tregs) are essential for immune tolerance, with cAMP metabolism central to their suppressive function. Inducible cAMP early repressor (ICER) is a negative regulator of cAMP signalling. However, its role in Treg biology is not fully understood. Here we generated Foxp3-specific ICER knockout mice to assess ICER&#8217;s function in Tregs. We found that ICER deficiency does not impair Treg development or suppression of effector T cell proliferation under homeostatic conditions. However, ICER-deficient Tregs display enhanced Foxp3 stability, increased glycolysis and proliferation but exhibit impaired suppression of IFN-\u03b3 production by effector T cells. In a dextran sodium sulphate-induced colitis model, loss of ICER in Tregs led to aggravated intestinal inflammation and tissue damage, without, however, a marked effect on gross disease parameters. These results identify ICER as a context-dependent modulator of Treg metabolism and inflammatory cytokine control, highlighting its potential role in regulating immune responses during inflammation.<\/p>","protected":false},"excerpt":{"rendered":"<p>This study is focussed on the role of cAMP-dependent transcriptional repressor ICER in regulatory T cell function. Using a conditional knockout model, Treg development, suppressive function, stability, and metabolic phenotype were examined to gain further understanding of the role of cAMP-dependent signalling in regulatory T cells. ABSTRACT Regulatory T cells (Tregs) are essential for immune &#8230; <a title=\"Inducible cAMP Early Repressor Limits Glycolytic Programming in Regulatory T Cells and Supports Control of Inflammatory Colitis. [[{&#8220;value&#8221;:&#8221;Aleksandra Lopez Krol, \nLuana Silva, \nDaniele C. Nascimento, \nSophie M. Oberwalder, \nHitikk Chawla, \nGabriel Alberto Barbosa de Carvalho, \nFatima Boukhallouk, \nMonica Romero, \nAnne Hausen, \nMatthias M. Gaida, \nLuciana Berod, \nJos\u00e9 Carlos Alves\u2010Filho, \nTim Sparwasser&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/10\/15\/inducible-camp-early-repressor-limits-glycolytic-programming-in-regulatory-t-cells-and-supports-control-of-inflammatory-colitis-valuealeksandra-lopez-krol-luana-silva-daniele-c-nascime\/\" aria-label=\"Read more about Inducible cAMP Early Repressor Limits Glycolytic Programming in Regulatory T Cells and Supports Control of Inflammatory Colitis. [[{&#8220;value&#8221;:&#8221;Aleksandra Lopez Krol, \nLuana Silva, \nDaniele C. Nascimento, \nSophie M. Oberwalder, \nHitikk Chawla, \nGabriel Alberto Barbosa de Carvalho, \nFatima Boukhallouk, \nMonica Romero, \nAnne Hausen, \nMatthias M. Gaida, \nLuciana Berod, \nJos\u00e9 Carlos Alves\u2010Filho, \nTim Sparwasser&#8221;}]]\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[112,42],"tags":[],"class_list":["post-79395","post","type-post","status-publish","format-standard","hentry","category-european-journal-of-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/79395","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=79395"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/79395\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=79395"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=79395"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=79395"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}