{"id":79428,"date":"2026-10-15T13:41:38","date_gmt":"2026-10-15T11:41:38","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/10\/15\/transient-manganese-exposure-reprograms-bone-marrow-derived-macrophages-toward-a-stable-anti-inflammatory-memory-state\/"},"modified":"2026-10-15T13:41:38","modified_gmt":"2026-10-15T11:41:38","slug":"transient-manganese-exposure-reprograms-bone-marrow-derived-macrophages-toward-a-stable-anti-inflammatory-memory-state","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/10\/15\/transient-manganese-exposure-reprograms-bone-marrow-derived-macrophages-toward-a-stable-anti-inflammatory-memory-state\/","title":{"rendered":"Transient manganese exposure reprograms bone marrow-derived macrophages toward a stable anti-inflammatory memory state"},"content":{"rendered":"<div>\n<p><b>J Immunol<\/b>. 2026 Oct 1;215(10):vkag267. doi: 10.1093\/jimmun\/vkag267.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Manganese ions (Mn2+) are potent immunomodulatory agents that activate the cGAS-STING pathway. While their role as acute adjuvants is well-documented, the innate immune memory (trained immunity) signatures induced by Mn2+ remain unexplored. Using an in vitro priming-rest-challenge model, we demonstrate that transient Mn2+ stimulation induces a persistent anti-inflammatory state in bone marrow-derived macrophages (BMDMs). Unlike the immediate proinflammatory burst associated with Mn2+, Mn2+-trained BMDMs displayed a stable reduction in Il6, Il1b, Il12a, and Nos2 expression upon secondary LPS or LPS + IFN-\u03b3 challenge. Furthermore, Mn2+ training enhanced IL-4-driven Arg1 induction and suppressed MHC class II surface expression, antigen presentation pathways, and phagocytic capacity against Candida albicans. Mechanistically, this functional attenuation was independent of glycolysis but correlated with a broad downregulation of lipid metabolic pathways. These findings reveal a lineage-specific regulatory &#8220;brake&#8221; induced by manganese, providing critical insights for its application in immunotherapy.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42876167\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=2985117R&amp;ff=20261015074137&amp;v=2.20.1\">42876167<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jimmun\/vkag267\">10.1093\/jimmun\/vkag267<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Immunol. 2026 Oct 1;215(10):vkag267. doi: 10.1093\/jimmun\/vkag267. ABSTRACT Manganese ions (Mn2+) are potent immunomodulatory agents that activate the cGAS-STING pathway. While their role as acute adjuvants is well-documented, the innate immune memory (trained immunity) signatures induced by Mn2+ remain unexplored. Using an in vitro priming-rest-challenge model, we demonstrate that transient Mn2+ stimulation induces a persistent &#8230; <a title=\"Transient manganese exposure reprograms bone marrow-derived macrophages toward a stable anti-inflammatory memory state\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/10\/15\/transient-manganese-exposure-reprograms-bone-marrow-derived-macrophages-toward-a-stable-anti-inflammatory-memory-state\/\" aria-label=\"Read more about Transient manganese exposure reprograms bone marrow-derived macrophages toward a stable anti-inflammatory memory state\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,71],"tags":[],"class_list":["post-79428","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-the-journal-of-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/79428","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=79428"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/79428\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=79428"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=79428"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=79428"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}