Wistar scientists have developed a new type of bispecific T cell engager, or BTE, that is effective against ovarian cancer in preclinical studies. It’s a major development for this type of immunotherapy, which has been used successfully against blood c…
Multiple sclerosis (MS) is a chronic autoimmune disorder that attacks the central nervous system. For years, Epstein-Barr virus (EBV) has been strongly linked to MS, as nearly every person diagnosed with the condition shows evidence of past EBV infecti…
Breastfeeding is widely recognized for its important role in supporting a child’s early growth and immune system development. Previous studies have found that exclusive breastfeeding for 4 to 6 months is associated with a lower risk of bronchial asthma…
A new Northwestern Medicine study has uncovered how a key immunoregulatory receptor plays an unexpected dual role in promoting T-cell exhaustion during chronic infection and cancer, according to findings published in the Proceedings of the National Aca…
Researchers at the Icahn School of Medicine at Mount Sinai have identified the immune cell that acts as the architect and coordinator of powerful immune hubs that form inside tumors and plays a key role in antitumor immunity. This discovery could lead …
We may age at different rates, but none of us escapes aging. A study in mice and human cells by Stanford Medicine researchers pins much of the blame on a particular type of immune cell’s increasing inability, with advancing age, to gobble up another im…
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer that is often diagnosed at advanced stages and carries a low five-year survival rate. Approximately 10% of cases are associated with hereditary predisposition caused by pathogenic mutation…
New research from The Kids Research Institute Australia suggests a simple dietary intervention during pregnancy could help protect against the increased risk of food allergies associated with antibiotics taken before birth.
A subset of cancers, known as microsatellite instability (MSI) and deficient DNA mismatch repair (dMMR) cancers, are more visible to the immune system than others. Because their DNA repair systems are defective, these tumors are more likely to be recog…
Researchers at The University of Texas MD Anderson Cancer Center have discovered a new way in which T cells attack acute myeloid leukemia (AML) cells, which may help explain why AML is particularly sensitive to immune-based treatments and could guide t…
Birds possess a specialized organ called the bursa of Fabricius that mammals do not have. It has long been thought that B cells, part of the immune system, develop exclusively in this organ. However, researchers from Tohoku University have discovered a…
Dozens of research teams around the world are working to halt, treat and even prevent Alzheimer’s disease, which silently develops in the brain for more than a decade before symptoms appear. Although recent years have brought important advances, resear…
Humans cannot fully heal spinal cord injuries. When the spinal cord is damaged, the body’s immune system often spirals into chaos. This overwhelming inflammatory response creates permanent scar tissue that stops nerve cells from ever repairing themselv…
A few hours after eating, an infant may suddenly experience a severe reaction that leaves his or her parents searching for answers. Such episodes may be caused by food protein-induced enterocolitis syndrome (FPIES), a condition that is often mistaken f…
Lincoln researchers are the first to show that metabolites produced by certain gut bacteria can positively affect the body’s immune response to cancer.
Prostate cancer is often resistant to immunotherapy, which harnesses a person’s immune system to recognize and destroy tumors. But a new technology that targets RNA in cancer cells gave immunotherapy new life, improving its ability to unleash cancer-ki…
Neuroimmunology, the study of interactions between the nervous and immune systems, is a rapidly growing field enabling new approaches for monitoring and treating inflammatory diseases. In a study published in Immunity, scientists showed that, in mice, …
Allergies can be minor or life-threatening, and current diagnostic blood tests are not always adequate for determining which substances patients need to avoid to prevent a reaction.
Researchers at The University of Texas MD Anderson Cancer Center have created a comprehensive single-cell map of the tumor immune microenvironment in multiple myeloma and its precursor conditions. The study provided insights that may explain why patien…
Why does the immune system become less effective as we age? A new USC study published in BMC Biology offers fresh insights by examining a key immune cell type across tissues: macrophages.
A novel oral vaccine platform using genetically engineered Bifidobacterium could enhance anti-tumor immunity. In an exploratory Phase I clinical study, the vaccine was well tolerated and generated immunologic and clinical findings that warrant further …
Picture this: You’re enjoying a summer lunch outdoors, unaware that beneath the table, a hungry mosquito is circling your ankles—until you feel the telltale bite. If that mosquito happens to be carrying a pathogen like West Nile virus (WNV), that bite …
Almost everyone carries Candida albicans. The yeast colonizes human mucous membranes—for example, the oral mucosa and the intestine—usually silently, without causing any problems. The immune system learns early on how to deal with it. It develops speci…
An international research group led by researchers from VUB-UZ Brussels and KU Leuven has demonstrated that a combined approach targeting both the immune system and insulin-producing beta cells can slow the progression of type 1 diabetes more effective…
New research has demonstrated a mechanistic link between the immune response to herpesviruses—the family of viruses related to cold sores, childhood infections and mononucleosis—and an increased risk of Alzheimer’s disease. A team of scientists from Ca…
The odds of human papillomavirus (HPV)-related cancers are higher among people with HIV (PWH) and solid-organ transplant recipients (SOTRs), according to a study published in JAMA Network Open.
Researchers at Tel Aviv University have developed one of the first experimental models that faithfully reproduces eosinophilic gastritis (EoG), a rare but increasingly recognized allergic disease of the stomach. Using this model, they identified the im…
An experimental drug called DT-109 reversed severe fatty liver disease in animal studies by repairing the gut and preventing harmful toxins from damaging the liver. The discovery could open the door to a new class of treatments for MASH and potentially…
A new study found that dietary fiber can determine whether beneficial intestinal worms help reduce inflammation or become essentially inactive. With plenty of fiber, the worms remained healthy and supported an anti-inflammatory response, while a low-fi…
People with chronic kidney disease (CKD) have a significantly increased risk of death from cardiovascular disease. They also suffer from chronic inflammation, the causes of which are still only partly understood. Oxalic acid (oxalate) has so far been k…
New research presented at the International Society for Stem Cell Research (ISSCR) 2026 Annual Meeting explores an approach that could expand the potential of cell replacement therapy for type 1 diabetes by evaluating whether immune-engineered, allogen…
A research team led by Professor Yoosoo Yang (Department of Integrative Biotechnology) of Sungkyunkwan University, in collaboration with the Korea Institute of Science and Technology (KIST) and Incheon National University, has developed a next-generati…
Researchers from Trinity College Dublin (TCD) and University College Dublin (UCD) have shown for the first time that a food supplement made from yeast helps the body make stronger immune cells that can fight cancer. The research teams found that adding…
Chronic and viral infections can literally exhaust certain key cells in the immune system from a constant barrage of attacks. But a new pair of papers by scientists at the Hackensack Meridian Center for Discovery and Innovation (CDI) points to a way to…
A new platform developed by researchers at the University of Texas MD Anderson Cancer Center quickly finds and isolates rare, tumor-reactive immune cells that are especially good at recognizing and attacking cancer cells, even without knowing which tum…
Researchers at the University of Sheffield have discovered that a fungus deadly to people with weakened immune systems can disable a critical defense used by neutrophils, the body’s front-line, infection-fighting white blood cells.
A King’s College London study, published in Nature Communications, offers insight into how long-term inflammation may contribute to cognitive decline in disorders such as Alzheimer’s disease, aging, depression and the lingering neurological effects of …
Scientists at UT Southwestern Medical Center have discovered that gut bacteria help regulate the development of the body’s immune system by directing the movement of vitamin A through a previously unrecognized cellular network. The preclinical findings…
Scientists have discovered that creatine may strengthen one of the immune system’s most important cancer-fighting pathways by energizing dendritic cells that activate killer T cells. The promising results could eventually help make immunotherapy more e…
Widely recognized as the face of food poisoning, salmonella bacteria lurk in raw meat and poultry, on pets, and in unpasteurized dairy products. If untreated, extreme cases can lead to full-body infections, like typhoid fever. UIC researcher Kiwook Kim…
A protein produced by gut immune cells orchestrates both immune protection against pathogens and immune tolerance of gut bacteria, according to a study led by Weill Cornell Medicine investigators. The discovery illuminates the complex biology of the gu…
A new “tumor-on-a-chip” model is giving scientists a live look at how pancreatic cancer can recruit the body’s own immune cells to help tumors survive. Researchers say the findings, published in Biofabrication, reveal possible new targets to weaken the…
A molecule linked to chronic inflammation disrupts the brain’s ability to create new neurons, uncovering a pathway with therapeutic potential for neurodegenerative diseases and neurological conditions. The King’s College London study, published in Natu…
In people with severely compromised immune systems, JC polyomavirus can trigger an untreatable, often fatal brain disease. An international research team has identified how virus mutations can strategically interfere with how human antibodies recognize…
A new HIV vaccine developed by La Jolla Institute for Immunology (LJI), Scripps Research scientists and IAVI has the potential to protect humans from developing HIV infection and AIDS. This HIV vaccine is the first to generate a high number of “broadly…
Chinese researchers have revealed the key role of iron in initiating allergic airway inflammation. The study, which was published in Cell, was conducted by a team led by Prof. Sun Bing from the Center for Excellence in Molecular Cell Science (Shanghai …
Researchers from Ann & Robert H. Lurie Children’s Hospital of Chicago identified a distinct subtype of eosinophilic esophagitis (EoE)—a chronic allergic inflammatory disorder in which the esophagus narrows, interfering with food passing properly. They …
A novel vaccination strategy against certain malignant brain tumors could fundamentally improve treatment for patients. Researchers from the German Cancer Research Center (DKFZ), Mannheim University Medical Center, Heidelberg University Hospital and nu…
An interdisciplinary team at Jena University Hospital achieved a surprisingly rapid and significant improvement in two patients with an autoimmune peripheral nervous system disorder. The team administered teclistamab, a drug originally developed for mu…
Stress, bad weather, strep throat, alcohol or cuts—there are a number of triggers that can set off psoriasis. At the same time, a great deal is happening in research on this skin disease, and new ways of controlling the immune system are being discover…
Genetically engineered CAR T cells expressing artificial receptor proteins are increasingly used in the clinic to boost the immune system’s response against leukemias and other cancers. In a study published in the Journal of Experimental Medicine (JEM)…
An Australian study by researchers at Peter Mac has shown that the natural protection against breast cancer offered by childbearing is due to the influx of killer T cells to the breast. The research shows that the cells begin to populate the breast dur…
A new intranasal DNA vaccine may give the immune system an extra weapon against tuberculosis by targeting bacteria that can hide from antibiotics. In animal studies, it helped clear infections faster, reduced lung inflammation, and prevented relapse af…
Unlike accidental cell death, some cells can actively decide to die through a controlled process. This is called programmed cell death and can occur in different forms, including apoptosis and necroptosis. Cells use this process when they are damaged, …
In the event of a severe heart attack, immature immune cells are released into the bloodstream from the bone marrow. A research team led by the University of Münster has demonstrated that the maturity level of neutrophils can be used to determine the s…
Children who have been in contact with dogs in early childhood are, on average, healthier and require fewer courses of antibiotics than children without such contact. The protective association is explained, at least in part, by the spread of dog-assoc…
Researchers at Karolinska Institutet have uncovered how serotonin-related metabolism helps regulate an understudied immune cell involved in allergic inflammation. The study, published in the journal Allergy, adds to knowledge about how allergic immune …
Researchers at Tel Aviv University’s Gray Faculty of Medical and Health Sciences have uncovered how a natural and essential immune system process can be hijacked to promote cancer progression. In a new study, the research team developed an advanced tec…
Infant feeding with whole goat milk formula (WGF) can reduce the incidence of atopic dermatitis (AD), especially in those with a parental history of AD, according to a study published in Clinical Nutrition.
Scientists have identified targets on the malaria-causing parasite that could be key to developing a universal vaccine against one of humankind’s oldest and deadliest diseases. Researchers from Oregon Health & Science University and collaborators acros…
T cells are an elite fighting force of the immune system, seeking out and destroying diseased cells. But in a prolonged campaign against a chronic condition—like a viral infection or cancer—the body needs a steady supply of these killer troops. Where a…
COVID-19 vaccine boosters not only protect against SARS-CoV-2—the virus behind the most recent pandemic—but may also help protect against some future coronaviruses that risk spreading from animals to humans, Cambridge researchers have shown.
Maternal cesarean section (CS) and maternal history of allergic diseases (MHAD) are independent and synergistic risk factors for allergic rhinitis (AR) in offspring, according to a study published online June 20 in the International Journal of Pediatri…
Summertime can bring a host of triggers for those with allergies and asthma. People often focus on spring and fall allergies, but summer allergies can take a toll on those affected. By learning more about seasonal allergies, you can better recognize th…
Lyme disease can be easiest to treat in its earliest stages, but current tests often miss infections during that critical window and cannot tell whether bacteria are still present or were cleared years ago. New research led by Tufts University School o…
Griffith University researchers have identified a key immune cell dysfunction in people with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), offering new clues about the condition.
Genetically predicted lower systolic blood pressure (SBP) seems to increase susceptibility to allergic rhinitis (AR), according to a study published online May 29 in Tobacco Induced Diseases.
For a vaccine to be effective, it must do two things. First, it must trigger an immune response. Second, the vaccine must train the body to remember the response so it can fight that same disease in the future. Now, new research shows that the only vac…
Scientists at the University of Oklahoma have identified a previously unrecognized immune system pathway that helps explain how cigarette smoking increases the risk of cardiovascular disease. The findings, published in Circulation Research, show that c…
More children are getting diseases such as celiac disease, type 1 diabetes and inflammatory bowel disease (IBD) than before, research shows. IBD is a term for conditions like ulcerative colitis and Crohn’s disease. These are all autoimmune diseases, wh…
Flu season is no longer just flu season. Since 2022, the health care community has faced what’s known as a “tripledemic” of seasonal influenza, COVID-19 and respiratory syncytial virus (RSV). That may mean the flu shot needs to become more than a flu s…
Researchers at Hospital for Special Surgery (HSS) have uncovered a critical link between the immune system in early life and its function in adulthood. The study, published in Science Immunology, identifies a new role for specialized skin immune cells,…
The technology that gave the world mRNA COVID vaccines is being tested in a variety of new ways, and emerging research reveals that a crucial T-cell population can be reprogrammed in animal models by reimagining the science that was introduced to the p…
Researchers at National Jewish Health have uncovered a previously unknown mechanism that helps drive inflammation in allergic asthma, offering new insight into how the disease develops and potentially revealing new targets for future therapies.
Scientists at UT Health San Antonio, the academic health center of The University of Texas at San Antonio, have found a link between a bacterium in the gut microbiome (ecosystem) and lupus that could lead to more effective treatment of the disease, des…
A new study has uncovered a key mechanism that helps one of the deadliest brain cancers evade the immune system, according to the study published in The Journal of Clinical Investigation.
For the immune system to effectively combat pathogens, antibody responses must be precisely controlled. So-called follicular regulatory T cells (Tfr cells) play a key role in this process by limiting excessive immune responses and helping to maintain i…
Chronic psychological stress can help tumors evade immune attack through a chain of molecular events involving gut bacteria and viruses within those bacteria, according to a study led by Weill Cornell Medicine investigators. The findings unveil a new l…
Leading CAR T cell therapy researchers have developed a human-in-the-loop artificial intelligence (AI) framework that centers scientists’ expertise to find viable target antigens for CAR T cell therapy. The work was led by experts from the Perelman Sch…
Researchers at Mayo Clinic have uncovered a previously hidden step in how the immune system prepares to fight cancer, a discovery that could help scientists develop more effective and longer-lasting cancer immunotherapies.
“Peacemaker” immune cells could help treat diseases ranging from type 1 diabetes to neurodegeneration by restoring immune tolerance, according to a new paper in Frontiers in Science.
New research, published in The Journal of Immunology, identifies biomarkers of a distinct immune profile that could be used to identify patients at risk for chronic critical illness (CCI) on admission to the intensive care unit (ICU) after traumatic in…
The immune system depends on molecular alarms that detect danger inside cells. One of these alarms is STING, short for “stimulator of interferon genes.” STING helps cells respond to infections, damaged DNA and cancer. When it activates at the right tim…
In autoimmune disorders, immune cells targeting “self” proteins are mistakenly activated, resulting in abnormal expansion and responsiveness. These disorders are known to reduce patients’ quality of life over a prolonged period. This can be attributed …
As the leading cause of viral gastroenteritis worldwide, norovirus is an all too familiar ailment. Its telltale digestive upset—not to mention its reputation for being notoriously contagious—has earned it the nicknames “winter vomiting bug” and “stomac…
As the leading cause of viral gastroenteritis worldwide, norovirus is an all too familiar ailment. Its telltale digestive upset—not to mention its reputation for being notoriously contagious—has earned it the nicknames “winter vomiting bug” and “stomac…
Researchers at Hospital for Special Surgery (HSS) have identified a specialized population of immune cells that plays a central role in driving abnormal tissue growth in rheumatoid arthritis (RA), offering new insight into disease progression and poten…
Researchers at Hospital for Special Surgery (HSS) have identified a specialized population of immune cells that plays a central role in driving abnormal tissue growth in rheumatoid arthritis (RA), offering new insight into disease progression and poten…
Systemic lupus erythematosus (SLE), the most common form of lupus, is an autoimmune disorder that occurs more frequently in women. Having multiple X chromosomes has been associated with an increased risk of developing lupus; however, the reason for thi…
A pilot study from Karolinska Institutet shows that immunotherapy may enable the stimulation of egg maturation in women with autoimmune POI (premature ovarian insufficiency)—a condition that usually leads to infertility. Three out of 10 women gave birt…
A parasitic worm might be the impetus behind a new generation of medicine. In a recent review in published in Clinical & Translational Immunology, Neima Briggs, MD, Ph.D., instructor of medicine (infectious diseases) at Yale School of Medicine, found t…
A quarter of the global population is estimated to have been infected with Mycobacterium tuberculosis, yet only 5%–10% of those infected go on to develop active tuberculosis (TB). “The big question has always been what distinguishes people who control …
For many people with asthma, air-quality advisories are harbingers of worsening symptoms. But for reasons science has struggled to explain, the extent to which pollution exacerbates asthma varies widely from person to person.
Type 1 diabetes is an autoimmune disease in which the immune system attacks the insulin-producing beta cells of the pancreas. Despite advances in glycemic control and the development of new immunotherapies, there is still a need to identify complementa…
Two new studies jointly published in Nature Communications reveal that certain species of fungi in the gut play a key role in the development of immune dysregulation and some pediatric allergic diseases—and may be promising targets for new therapies.
Scientists from the University of Bath (UK) have shed new light on how Crohn’s disease develops and why it affects people differently after finding new evidence of a link between a key immune system gene in the gut and signaling of the hormone estrogen.
Scientists discovered that kombucha’s flavor, chemistry, and antioxidant activity vary dramatically depending on the tea used to make it. Green and oolong tea kombuchas emerged as the most biologically active, while fermentation transformed each tea in…
Strange “chimeric” RNA once thought to be the product of cancer is actually an important controller of women’s health, including influencing their susceptibility to infectious disease and autoimmune disorders, new University of Virginia School of Medic…
