J Immunol. 2026 May 14;215(5):vkag075. doi: 10.1093/jimmun/vkag075.
ABSTRACT
Among the PI3K isoforms, PI3Kδ has attracted particular attention from immunologists and hematologists. Despite earlier clinical setbacks, the PI3Kδ field has recently re-emerged with renewed promise. Here, I highlight key milestones in the evolving understanding of PI3Kδ signaling in immunity and cancer, and pivotal studies that have shaped this field.
PMID:42153522 | DOI:10.1093/jimmun/vkag075