Publicaciones
Integrating multi-omics and machine learning to reveal IL1R2-driven macrophage-fibroblast spatial interactions in polycyclic aromatic hydrocarbon-induced pulmonary fibrosis
BackgroundPolycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental toxicants, yet the toxicological mechanisms by which they induce idiopathic pulmonary fibrosis (IPF) remain poorly understood. This study aims to systematically elucidate th…
Brentuximab vedotin plus CHP-like versus CHOEP regimen for the first-line treatment of PTCL patients: a multi-center propensity-matched retrospective study
IntroductionThe optimal frontline treatment option for Peripheral T-cell lymphomas (PTCLs) has not been completely defined.MethodsTo compare the efficacy and safety of brentuximab vedotin (BV) combined with CHP-like regimen (cyclophosphamide, an anthra…
Inducible and reversible in vivo protein degradation reveals T cell-intrinsic regulatory function of SHP-1
Scientific problemStudying the acute, cell-intrinsic functions of signaling proteins in T cells has long been challenging. Existing constitutive or inducible gene deletion cannot overcome developmental adaptation that obscures true phenotypes. Similarl…
Nanotechnology for next-generation CAR T-Cell manufacturing
Chimeric antigen receptor (CAR) T-cell therapy has transformed the treatment landscape of hematological malignancies; however, its broader clinical implementation remains constrained by the complexity, cost, and variability of current manufacturing wor…
Eribulin mesylate in combination with ivonescimab as first-line treatment for unresectable locally advanced or metastatic triple-negative breast cancer(EMIT): study protocol for a single-arm, multicenter clinical trial
BackgroundAdvanced triple-negative breast cancer (TNBC) has an extremely poor prognosis, and current therapies offer limited benefits for patients with low programmed cell death ligand 1(PD-L1) expression. This study innovatively proposes a “novel chem…
Context-dependent functions of insulin, IGF, and GLP signaling in inflammatory bowel disease: linking metabolism, immunity, and intestinal homeostasis
Inflammatory bowel disease (IBD), encompassing Crohn’s disease and ulcerative colitis, is a chronic relapsing inflammatory disorder of the gastrointestinal tract characterized by dysregulated immune responses, impaired epithelial barrier function, and …