Immunotherapy resistance in kidney cancer driven by myeloid cell signaling
Immunotherapy with immune checkpoint inhibitors is standard first-line treatment for advanced renal cell carcinoma (RCC), but not every patient responds.
Immunology news
Could a cancer vaccine developed long ago hold the key to long-term survival in breast cancer?
A small group of women with advanced breast cancer received a vaccine via a clinical trial more than 20 years ago. Today, they’re all still alive. Scientists say that kind of long-term survival is almost unheard of for patients with metastatic breast c…
DNA copy-number changes help melanoma develop resistance to immunotherapy, study finds
A study led by UCLA Health Jonsson Comprehensive Cancer Center investigators reveals how melanoma, the deadliest form of skin cancer, evolves to resist immunotherapy and identifies a potential strategy to prevent or reverse that resistance.
Researchers unravel mystery behind rare pregnancy disorder
Leiden researchers have found clues to why a rare pregnancy disorder is mild in some babies but life-threatening in others. Their discovery opens the door to a test that could identify severe cases during pregnancy. Fortunately, a treatment already exi…
Restoring youthful microvascular function to aging skin
The New York University School of Medicine and collaborators found that capillary-associated macrophages in skin decline with age, weakening microvascular repair and reducing perfusion in mice, with skin restoration possible after boosting local macrop…
Early clinical trial tests immune-boosting therapy before prostate cancer surgery
A small, early clinical trial led by the Icahn School of Medicine at Mount Sinai and collaborators has shown that directly injecting an immune-activating compound into prostate tumors before surgery appears safe and may help the immune system recognize…
Dual studies uncover complementary strategies to overcome resistance to KRAS G12C inhibitors in lung cancer
Two companion studies published in Cancer Research by scientists at Moffitt Cancer Center identify distinct but complementary approaches to overcoming drug resistance in KRAS G12C-mutant non-small cell lung cancer.
How Staph aureus reshapes immune system in children with rare genetic skin disorder
Scientists have demonstrated for the first time how Staphylococcus aureus—a leading cause of skin infections—reshapes the immune system’s inflammatory responses in children with a rare skin condition.
The thymus hosts more ‘cellular teachers’ than we thought, study finds
A Czech scientist has contributed to understanding the function of the thymus—the training center of the immune system. T lymphocytes, key defensive cells, learn in the thymus not to mistake the body’s own tissues for foreign enemies.
Immune cell subset reveals biological age beyond chronological years
Ben-Gurion University of the Negev’s Prof. Alon Monsonego had discovered that T helper lymphocytes, a subset of immune cells which regulate immunity, undergo functional changes with age. These changes can indicate the biological age of individuals, whi…