The Journal of Immunology

J Immunol. 2026 Apr 15;215(4):vkag076. doi: 10.1093/jimmun/vkag076. ABSTRACT A large body of evidence indicates that Th17 cells play essential roles in mucosal immune responses and trigger autoimmune diseases, including multiple sclerosis, inflammatory bowel disease, and psoriasis. Targeting Th17 cells holds promise for therapeutic innovation. While the core cytokine signaling networks driving Th17 differentiation have been … Read more

J Immunol. 2026 Apr 15;215(4):vkag077. doi: 10.1093/jimmun/vkag077. ABSTRACT Tissue-resident monocyte-lineage cells (TRMCs) are an extravascular population distinct from circulating monocytes and synovial macrophages and are critical for the development of inflammatory arthritis. However, the precise identities and origins of TRMC subpopulations remain unclear. Here, we characterize the ontogeny of TRMCs, which are comprised of bone … Read more

J Immunol. 2026 Apr 15;215(4):vkag086. doi: 10.1093/jimmun/vkag086. ABSTRACT Hematopoietic stem cell transplantation as treatment for patients with leukemia relies on chemotherapy and/or irradiation-based conditioning regimens to prevent graft rejection and cancer relapse. Despite advances in radiotherapy, total body irradiation for myeloablative conditioning is associated with dose and temporal heterogeneity, and how these variables impact thymus … Read more

J Immunol. 2026 Apr 15;215(4):vkag084. doi: 10.1093/jimmun/vkag084. ABSTRACT Plasma cells (PCs) are terminally differentiated B cells that are long-lived and have high rates of protein secretion. Because of these features, ex vivo generated PCs are being developed as therapeutics for long-term protein delivery. Here, we used proteomics and flow cytometry-based approaches to comprehensively interrogate the … Read more

J Immunol. 2026 Apr 15;215(4):vkag078. doi: 10.1093/jimmun/vkag078. ABSTRACT Genetically modified chimeric antigen receptor (CAR) T cells eliminate tumors by recognizing specific antigens on the cell surface. T cell ion channels (e.g. Kv1.3, KCa3.1) influence activation, proliferation, and effector functions such as target cell killing, through the regulation of Ca2+ signaling. We showed that CAR-expressing cells … Read more

J Immunol. 2026 Apr 15;215(4):vkag081. doi: 10.1093/jimmun/vkag081. ABSTRACT The innate immune system has evolved as the primary response mechanism against microbial infections, tissue damage, and cellular stress. Signals that disrupt homeostasis are sensed by pattern recognition receptors and initiate innate immune responses to restore homeostasis. Some intracellular pattern recognition receptors belonging to the Nod-like receptor, … Read more

J Immunol. 2026 Apr 15;215(4):vkag092. doi: 10.1093/jimmun/vkag092. ABSTRACT Emerging evidence from lupus-prone mice and patients with systemic lupus erythematosus implicates enhanced glycolysis in lymphocytes as a driver of disease. We previously showed that the pharmacologic blockade of glycolysis reduced the production of autoantibodies without affecting antibodies induced by immunization to a foreign protein. Here we … Read more

J Immunol. 2026 Apr 15;215(4):vkag088. doi: 10.1093/jimmun/vkag088. ABSTRACT Systemic lupus erythematosus (SLE) is a systemic autoimmune disease in which immune complexes (ICs) consisting of antinuclear autoantibodies (ANAs) and nuclear antigens induce complement activation and contribute to disease pathogenesis. The impact of antigen form on ICs formation and subsequent complement activation is not well understood. To … Read more

J Immunol. 2026 Apr 15;215(4):vkag073. doi: 10.1093/jimmun/vkag073. ABSTRACT Mucosal-associated invariant T (MAIT) cells are unconventional T cells, which upon activation can display potent cytotoxic and cytokine-producing capabilities. Together, these features make MAIT cells promising candidates for cancer immunotherapy. In this study, we show that MAIT cells can be efficiently amplified in vitro, and these amplified … Read more

J Immunol. 2026 Apr 15;215(4):vkag072. doi: 10.1093/jimmun/vkag072. ABSTRACT Ventricular arrhythmias are a primary cause of sudden cardiac death after acute myocardial infarction (AMI). Both β1-adrenergic autoantibodies (β1-AA) and nociceptin/orphanin FQ (N/OFQ) are implicated in AMI, but their potential interaction in ischemic arrhythmogenesis remains unclear. This study investigated the interplay between N/OFQ and β1-AA and the … Read more