inmunoadmin

4-Octyl itaconate suppresses IFN-γ-induced MHC II expression in bone marrow-derived macrophages

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J Immunol. 2026 Oct 1;215(10):vkag255. doi: 10.1093/jimmun/vkag255. ABSTRACT Macrophages function as professional antigen-presenting cells that integrate inflammatory signals with metabolic reprogramming to shape immune responses. Itaconate, an immunometabolite derived from ACOD1/IRG1 activity in activated macrophages, has been implicated in the regulation of inflammatory responses, yet its role in interferon γ (IFN-γ)-driven antigen presentation programs remains … Read more

Phenotypic and functional characterization of porcine T follicular helper and regulatory cells

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J Immunol. 2026 Oct 1;215(10):vkag264. doi: 10.1093/jimmun/vkag264. ABSTRACT T follicular helper (Tfh) cells provide help to B cells for antibody class switching and affinity maturation and are critical for germinal center (GC) formation. The frequency of Tfh cells has proven to be a valuable marker for predicting durable neutralizing antibody responses; conversely, the expansion of … Read more

Context-dependent regulation of cytotoxic T lymphocytes by nuclear receptors

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J Immunol. 2026 Oct 1;215(10):vkag261. doi: 10.1093/jimmun/vkag261. ABSTRACT Cytotoxic CD8⁺ T lymphocytes eliminate pathogen-infected and malignant cells through migration to affected tissues, cytokine production, and cytotoxic activity. A mounting body of evidence indicates that CD8 T cell differentiation into functionally different subsets, such as effector, memory, tissue-resident memory, and exhausted T cells, is controlled by … Read more

CTH522/CAF01 vaccination elicits clonally related Th17 subsets that mediate IL-17A-dependent protection against Chlamydia trachomatis

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J Immunol. 2026 Oct 1;215(10):vkag265. doi: 10.1093/jimmun/vkag265. ABSTRACT Chlamydia trachomatis is the leading bacterial sexually transmitted pathogen worldwide and a major cause of reproductive tract disease, highlighting the need for an effective vaccine. Defining the immune mechanisms underlying vaccine-induced protection is therefore critical. We previously demonstrated that in mice vaccinated with CTH522/CAF01, genital tract Th17 … Read more

Improving peptide vaccine manufacturability without sacrificing immunogenicity: substitution of methionine and cysteine with oxidation-resistant isosteres

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J Immunol. 2026 Aug 29;215(9):vkag232. doi: 10.1093/jimmun/vkag232. ABSTRACT Vaccines comprising peptide antigens for inducing T cell immunity are being developed for a broad range of therapeutic applications including prevention and treatment of cancer, autoimmunity, and infectious diseases. However, many peptide antigens contain cysteine and/or methionine, which are prone to form oxidation products that can present … Read more

A Novel Sulfatide Analog Recognized by Human iNKT Cells Enhances Polyfunctional Antigen‐Specific CD8+ T Cell Responses. [[{“value”:”Ayaka Hara, Julia DiSapio, Morgan Coombs, Seketoulie Keretsu, Svetlana Korinfskaya, Guzal Khayrullina, Vibhuti Joshi, Md Masud Alam, Hye Kim, Nargis Malik, Emily E. Steffke, Laila Latifi, John C. Hancock, Jo D. Spurgeon, Byram H. Ozer, Mark R. Gilbert, Amy R. Howell, Masaki Terabe”}]]

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The sulfatide analog SAP-3 activated ex vivo iNKT cells, improving the quality of antigen-specific CD8+ T cell responses. SAP-3 is a promising novel vaccine adjuvant candidate that enhances antitumor immune responses. ABSTRACT Invariant natural killer T (iNKT) cells are CD1d-restricted T cells that recognize lipid antigens. Studies of analogs of a prototypic iNKT cell antigen, … Read more

Live versus killed Listeria monocytogenes immunization differentially programs Hup-specific CD4+ T cell responses with distinct protective outcomes

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J Immunol. 2026 Aug 29;215(9):vkag253. doi: 10.1093/jimmun/vkag253. ABSTRACT The histone-like protein Hup is a highly conserved DNA-stabilizing and compacting protein found across bacterial families. We previously demonstrated that the Hup protein of Staphylococcus and Streptococcus species harbors a shared CD4+ T cell epitope, and that Hup77-88-specific CD4+ T cells confer cross-species protection against pulmonary infection … Read more

ZFP335-MYBL2 transcriptional axis orchestrates Th17 cell differentiation and psoriatic inflammation

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J Immunol. 2026 Aug 29;215(9):vkag260. doi: 10.1093/jimmun/vkag260. ABSTRACT T helper 17 (Th17) cell differentiation is governed by a complex transcriptional network centered on the lineage-specifying factor RORγt, accompanied by STAT3, IRF4, and SMAD2/3. However, the complete repertoire of transcriptional regulators controlling Il17a gene transcription and Th17 commitment remains incompletely defined. Here, we identify zinc finger … Read more

Interferon‐α–Driven Stratification of B Cells Reveals Metabolic Reprogramming of Double‐Negative, Naïve, and Transitional Cell Subsets and Refines Molecular Classification in Sjögren’s Disease. [[{“value”:”Cristian Iperi, Akhiya Anilkumar Rekha, Gustav Arvidsson, Gunnel Nordmark, Eleonore Bettacchioli, Marie Frutoso, Marta Alarcón‐Riquelme, Jessica Nordlund, Ann‐Christine Syvänen, PRECISESADS Flow Cytometry Study Group, PRECISESADS Clinical Consortium, Valérie Devauchelle‐Pensec, Divi Cornec, Sophie Hillon, Christophe Jamin, Anne Bordron”}]]

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Our study reveals reduced B-cell OXPHOS and translation in both IFN-positive and IFN-negative Sjögren’s patients. IFN-positive patients display expansion of naïve-IFN, transitional and double-negative B cells with increased glycolysis, amino-acid metabolism, NF-κB signaling and autophagy. The B-cell–specific IFN score shows superior clinical correlations to autoantibodies than other immune cells. ABSTRACT Sjögren’s disease (SjD) is a … Read more

Mechanism of SGLT2 inhibitors in improving immune imbalance in diabetic mice with sepsis via regulating macrophage M2 polarization through the APOC1/HMGB1/TLR4 axis

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J Immunol. 2026 Aug 29;215(9):vkag240. doi: 10.1093/jimmun/vkag240. ABSTRACT This study aimed to investigate the mechanism by which the sodium-glucose cotransporter-2 (SGLT2) inhibitor dapagliflozin improves immune imbalance in sepsis with diabetes, focusing on its regulation of macrophage M2 polarization through the APOC1/HMGB1/TLR4 axis. A mouse model of type 2 diabetes was established through intraperitoneal injection of … Read more

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