European Journal of Immunology

Discovery of Avian TCRVβ2+ T Cells Recognizing the Endogenous Ganglioside via a chCD1.1‐Dependent Pathway. [[{“value”:”Nitin Kamble, Faisal R Anjum, Shahriar Behboudi”}]]

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We present the first report of chicken lipid-reactive, NKT-like TCRVβ2+ T cells that recognize the endogenous ganglioside GM3 presented by chCD1.1 on live antigen-presenting cells. This activation induces a rapid cytokine response from avian lipid-reactive T cells, offering a universal target for lipid-adjuvanted poultry vaccines. ABSTRACT This study presents the discovery and first functional characterization … Read more

Inducible cAMP Early Repressor Limits Glycolytic Programming in Regulatory T Cells and Supports Control of Inflammatory Colitis. [[{“value”:”Aleksandra Lopez Krol, Luana Silva, Daniele C. Nascimento, Sophie M. Oberwalder, Hitikk Chawla, Gabriel Alberto Barbosa de Carvalho, Fatima Boukhallouk, Monica Romero, Anne Hausen, Matthias M. Gaida, Luciana Berod, José Carlos Alves‐Filho, Tim Sparwasser”}]]

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This study is focussed on the role of cAMP-dependent transcriptional repressor ICER in regulatory T cell function. Using a conditional knockout model, Treg development, suppressive function, stability, and metabolic phenotype were examined to gain further understanding of the role of cAMP-dependent signalling in regulatory T cells. ABSTRACT Regulatory T cells (Tregs) are essential for immune … Read more

Cover Story: Eur. J. Immunol. 10’26.

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Our cover features images related to flow cytometry techniques widely used for analysis of function and phenotypes of major human and murine immune cell subsets, superimposed on a multidimensional immune cell population scatter plot. These images are taken from the third edition of EJI’s Flow Cytometry Guidelines by Cossarizza et al., a comprehensive resource prepared … Read more

Synovial Fluid Immune Cell Landscape in Juvenile Idiopathic Arthritis. [[{“value”:”Viola Pitkänen, Bella Lappalainen, Marja Rytkönen‐Nissinen, Terhi Remes‐Pakarinen, Paula Vähäsalo, Milja Möttönen, Minna‐Maija Grönlund, Miika Arvonen, Liisa Kröger, Anna‐Mari Schroderus, Tuure Kinnunen”}]]

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Synovial fluid immune cells in juvenile idiopathic arthritis were profiled using single-cell multiomics and flow cytometry. The immune landscape in synovial fluid was markedly distinct from that of blood and was enriched for dendritic cells, CD56hi NK cells, γδ T cells, CD4+ T peripheral helper and regulatory T cells, tissue-resident memory CD8+ T cells, and … Read more

Parasite‐Derived IL‐33 Inhibitors Prevent Bleomycin‐Induced Lung Fibrosis. [[{“value”:”Samuele Di Carmine, Tania Frangova, Suzanne H. Hodge, Danielle J. Smyth, Tera Birchall, Josh Richards, Ian Newton, Sarah Kelly, Alice R. Savage, E. Suzanne Cohen, J. Simon C. Arthur, Henry J. McSorley”}]]

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Infection with the intestinal helminth Heligmosomoides polygyrus bakeri, or administration of the parasite products (HES), or administration of recombinant HpARI2+HpBARI_Hom2 can all suppress the development of lung fibrosis in the mouse bleomycin model, via suppression of the IL-33 pathway. Graphic abstract created in BioRender. McSorley, HJ. (2026) https://BioRender.com/8ag7ll4. ABSTRACT Idiopathic pulmonary fibrosis (IPF) is a … Read more

PGE2 Enhances Human ILC3 Function but Constrains ILC2‐to‐ILC3 Plasticity. [[{“value”:”Lorenz Wirth, Whitney Weigel, Efthymia Kokkinou, Johan Kolmert, Anna‐Karin Johnsson, Alessandro Quaranta, Craig Wheelock, Mattias Jangard, Ram V. Pandey, Sven‐Erik Dahlén, Christopher Andrew Tibbitt, Thomas Hochdörfer, Jenny Mjösberg”}]]

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Distinct prostaglandin circuits regulate human ILC2 and ILC3 function. ILC3-derived PGE2 promotes type 3 cytokine production, whereas hybrid ILC2/3 generated during plasticity retain an inhibitory response to PGE2 despite acquiring ILC3-like features. ABSTRACT Type 2 innate lymphoid cells (ILC2) drive eosinophilic asthma, whereas ILC3 and plastic ILC2/3 states are implicated in neutrophilic and mixed granulocytic … Read more

A Novel Sulfatide Analog Recognized by Human iNKT Cells Enhances Polyfunctional Antigen‐Specific CD8+ T Cell Responses. [[{“value”:”Ayaka Hara, Julia DiSapio, Morgan Coombs, Seketoulie Keretsu, Svetlana Korinfskaya, Guzal Khayrullina, Vibhuti Joshi, Md Masud Alam, Hye Kim, Nargis Malik, Emily E. Steffke, Laila Latifi, John C. Hancock, Jo D. Spurgeon, Byram H. Ozer, Mark R. Gilbert, Amy R. Howell, Masaki Terabe”}]]

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The sulfatide analog SAP-3 activated ex vivo iNKT cells, improving the quality of antigen-specific CD8+ T cell responses. SAP-3 is a promising novel vaccine adjuvant candidate that enhances antitumor immune responses. ABSTRACT Invariant natural killer T (iNKT) cells are CD1d-restricted T cells that recognize lipid antigens. Studies of analogs of a prototypic iNKT cell antigen, … Read more

Interferon‐α–Driven Stratification of B Cells Reveals Metabolic Reprogramming of Double‐Negative, Naïve, and Transitional Cell Subsets and Refines Molecular Classification in Sjögren’s Disease. [[{“value”:”Cristian Iperi, Akhiya Anilkumar Rekha, Gustav Arvidsson, Gunnel Nordmark, Eleonore Bettacchioli, Marie Frutoso, Marta Alarcón‐Riquelme, Jessica Nordlund, Ann‐Christine Syvänen, PRECISESADS Flow Cytometry Study Group, PRECISESADS Clinical Consortium, Valérie Devauchelle‐Pensec, Divi Cornec, Sophie Hillon, Christophe Jamin, Anne Bordron”}]]

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Our study reveals reduced B-cell OXPHOS and translation in both IFN-positive and IFN-negative Sjögren’s patients. IFN-positive patients display expansion of naïve-IFN, transitional and double-negative B cells with increased glycolysis, amino-acid metabolism, NF-κB signaling and autophagy. The B-cell–specific IFN score shows superior clinical correlations to autoantibodies than other immune cells. ABSTRACT Sjögren’s disease (SjD) is a … Read more

MRP8‐Cre Transgenic Mice Are Resistant to Weight Gain and Diet‐Induced Obesity Independently of Neutrophils. [[{“value”:”Stephan Forisch, Fatemeh Soltani, Laia Salvat Costa, Beatriz M. Cardoso, Yaiza Moreno Galiano, Cedric Duval, Robert A. S. Ariëns, Navdeep S. Chandel, Mari T. Kaartinen, Stefanie K. Wculek”}]]

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The MRP8Cre mouse model is frequently used to investigate the biology of neutrophils. This study reports that MRP8Cre transgenic have a lower body weight and improved metabolic health, especially after high fat diet feeding, which correlates with decreased Serpine1/PAI-1 expression in metabolic organs. Image created with BioRender.com. ABSTRACT Obesity is a major risk factor for … Read more

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