Open access, Reviews
Mechanisms of neuropeptide-mediated immune sensing in the modulation of antitumor immunity
The hallmarks of cancer, first introduced by Hanahan and Weinberg in 2000 and updated in 2011 and in 2022, summarize the core processes that drive the stepwise development of tumors. This framework has proven highly effective for interpreting the vast…
TAMing the tumor: targeting immune inhibitory receptors on tumor-associated macrophages in pediatric brain tumors – an emerging immunotherapy strategy
Brain tumors are the most common solid tumors in children. Despite recent advancements in cancer survival, the prognosis for high-grade pediatric brain tumors remains poor, with treatments resulting in severe long-term side effects. Over the last deca…
RAS signaling at the crossroads of radioresistance and tumor immunity
RAS mutations are among the most prevalent oncogenic drivers in solid tumors and are consistently associated with suboptimal responses to radiation therapy (RT). Within this family, KRAS is the dominant isoform and a central regulator of tumor stress …
Emerging role of microRNAs as modulators of the tumor immune microenvironment
The advent of immune checkpoint inhibitors (ICIs) has transformed the treatment landscape of several malignancies, but durable clinical benefits are only observed in a subset of patients. Primary and acquired resistance to immunotherapy, largely drive…
Tumor cell ferroptosis in antitumor immunity and immunotherapy efficacy
Cancer immunotherapy, particularly immune checkpoint blockade (ICB), has represented a major advancement for the treatment of various cancers. Though ICB has been an effective tool in the clinical management of patients, a significant subset of indivi…
Advances in immunotherapies in ovarian cancer
Ovarian cancer (OC) remains one of the deadliest gynecologic malignancies, and, despite the presence of tumor-infiltrating lymphocytes (TILs) in nearly half of cases, immune checkpoint inhibitors have shown only modest clinical benefit. These observat…
Mapping the TCR landscape: computational tools empowering translational immunology and therapy design
T cell receptors (TCRs) are central to adaptive immunity, yet their vast sequence and structural diversity present a significant challenge to fully understand immune responses. The application of high-throughput sequencing technologies, including bulk…
Targeting macrophage-driven NK cell immunosuppression to improve cancer immunotherapy
Natural killer (NK) cells are critical effectors of antitumor immunity, however their cytotoxic function is frequently impaired within the tumor microenvironment (TME). Tumor-associated macrophages (TAMs), the most abundant immune stromal population i…