European Journal of Immunology

Ryanodine Receptor 1 Is Dispensable for CD4+ T‐Cell Differentiation and Effector Function in Intestinal Inflammation Models. [[{“value”:”Sogol Dostiar Tabrizi, Mikolaj Nawrocki, Tanja Bedke, Marius Böttcher, Friederike Stumme, Melina Birus, Franziska Möckl, Lola Hernandez, Björn‐Phillip Diercks, Nicola Gagliani, Dmitri Lodygin, Alexander Flügel, Andreas H. Guse, Hans‐Willi Mittrücker, Samuel Huber”}]]

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Ryr1 deletion reduces Ca2+ microdomains and delays global Ca2+ signaling in naïve CD4+ T cells but does not impair their activation, proliferation, or differentiation in vitro. Despite altered Ca2+ signaling, Ryr1 expression in CD4+ T cells was dispensable for their pathogenicity in murine models of intestinal inflammation. ABSTRACT T-cell receptor (TCR) signaling is necessary for … Read more

Rapid and Highly Efficient CRISPR‐Cas9 RNP Genome Editing in Primary ILC2s. [[{“value”:”Arianna Maria Candelotti, Giordana Garzillo, Sara Bartolini, Chiara Di Censo, Giovanna Peruzzi, Helena Stabile, Cinzia Fionda, Giuseppe Sciumè, Giuseppe Pietropaolo”}]]

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CRISPR-mediated gene editing enables efficient genetic manipulation of ILC2s through ex vivo or in vivo activation and Cas9 RNP delivery. This platform provides a robust approach to dissect gene function in ILC2s, with minimal manipulation.

From Advocacy to Action: The yEFIS Perspective on Women in Immunology and Persistent Barriers. [[{“value”:”Marie‐Louise Diefenbach‐Wilke, Marija Rakić, Ewa Oleszycka, Ines Poljak, Melissa van Gool”}]]

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The yEFIS Women in Science campaigns highlighted the achievements of women in immunology while raising awareness of persistent structural barriers, fostering dialogue, networking and greater recognition of gender equity in science.

Analysis of Human Thymopoiesis Reveals Rapid Postnatal Remodeling of Thymocytes Within the First 3 Months of Life. [[{“value”:”Camille Kergaravat, Jean‐Marc Doisne, Clarisse Godard, Agata Cieslak, Mourad Amrane, David Vermijlen, Vahid Asnafi, Kamel Benlagha, James P. Di Santo, Emmanuel Clave, Antoine Toubert”}]]

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Human thymopoiesis undergoes a dynamic postnatal transition, revealing maximal intrathymic sjTREC production at birth, shifts in thymocyte phenotype and composition, and a transient wave of effector Vδ2+ γδ T cells during early infancy. ABSTRACT The thymus generates a diverse and self-tolerant T-cell repertoire. Its development and output undergo profound changes from fetal to early postnatal … Read more

Cover Story: Eur. J. Immunol. 8’26.

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Our cover features images related to flow cytometry techniques widely used for analysis of function and phenotypes of major human and murine immune cell subsets, superimposed on a multidimensional immune cell population scatter plot. These images are taken from the third edition of EJI’s Flow Cytometry Guidelines by Cossarizza et al., a comprehensive resource prepared … Read more

The Respiratory Epithelial Barrier as an Immunopharmacological Rheostat: From Homeostatic Sentinel to Therapeutic Target in Chronic Lung Disease. [[{“value”:”Feng‐Xian Ni, Jie Hu, Hui‐Hui Chen, Dong‐Hui Huang, Ze‐Bo Jiang”}]]

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This review introduces the “Epithelial Immunopharmacological Rheostat,” a framework where the respiratory epithelium calibrates immune tolerance versus inflammation through four interacting axes. Dysregulation of these axes drives chronic lung diseases, offering a roadmap for precision therapies that reset the rheostat. ABSTRACT The respiratory epithelium is a dynamic immunopharmacological interface that transcends its traditional role as … Read more

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