Decoding complement: Novel disease insights and therapeutic horizons. [[{“value”:”Christian M. Karsten, Jörg Köhl”}]]
European Journal of Immunology, EarlyView.
European Journal of Immunology
CD24 regulates liver immune response and ameliorates acute hepatic injury through controlling hepatic macrophages. [[{“value”:”Jian Zheng, Jun Xiao, Yatong Fan, Honggang Zheng, Hongyu Liu, Jie Xiang, Lei Hai, Yan Wang, Xuejun Zhang”}]]
CD24 on hepatic macrophages limits liver injury by interacting with Siglec-G and inhibiting inflammatory pathways. CD24 deficiency exacerbates liver damage, underscoring its potential as a therapeutic target for liver diseases. Abstract Liver injury releases danger-associated molecular patterns, which trigger the immune response. CD24 negatively regulates the immune response by binding with danger-associated molecular patterns, but … Read more
Blood transcriptome profiling reveals distinct gene networks induced by mRNA vaccination against COVID‐19. [[{“value”:”Lennart Riemann, Leonie M. Weskamm, Leonie Mayer, Ivan Odak, Swantje Hammerschmidt, Inga Sandrock, Michaela Friedrichsen, Inga Ravens, Janina Fuss, Gesine Hansen, Marylyn M. Addo, Reinhold Förster”}]]
Using an unsupervised weighted gene correlation analysis on blood transcriptomes pre- and post-COVID-19 mRNA vaccination, we identify distinct gene networks that are up- and downregulated in response to vaccination. A particular interferon-associated network significantly correlated with induced antibody levels and was further characterized, for example, by identifying network hub genes. Abstract Messenger RNA (mRNA) vaccines … Read more
IL‐17A‐producing γδ T cells: A novel target in stroke immunotherapy. [[{“value”:”Marius Piepke, Alina Jander, Nicola Gagliani, Mathias Gelderblom”}]]
In stroke, γδ T cells orchestrate the postischemic immune response in the CNS through their IL-17A production. Notably, the intestinal microbiota and the diet influence IL-17A levels in γδ T cells, offering the potential to modulate γδ17 T cells in the postischemic CNS and to improve stroke outcome. Abstract The activation of the immune system … Read more
Bridging the gap: Insights in the immunopathology of Lyme borreliosis. [[{“value”:”Marijn E. Snik, Noor E.I.M. Stouthamer, Joppe W. Hovius, Melissa M.J. van Gool”}]]
Lyme borreliosis is caused by Borrelia burgdorferi sensu lato transmitted by Ixodes ticks. The disease progresses from early localized infection to more severe conditions driven by ongoing inflammation. Understanding the role of Th1/Th2 balance, B-cell dysfunction, and autoimmunity in Lyme borreliosis pathogenesis could improve diagnosis and treatment strategies. Abstract Lyme borreliosis (LB), caused by Borrelia … Read more
PP2A catalytic subunit alpha is critically required for CD8+ T‐cell homeostasis and antibacterial responses. [[{“value”:”Xian Zhou, Meilu Li, Minji Ai, Yanfeng Li, Xingxing Zhu, Michael J. Hansen, Jun Zhong, Kenneth L. Johnson, Roman Zenka, Akhilesh Pandey, Larry R. Pease, Hu Zeng”}]]
Graphical Abstract: Using a genetic model lacking PP2A catalytic subunit alpha (PP2A Cα) specifically in T cells, we demonstrated that PP2A Cα is essential for maintaining CD8+ T-cell homeostasis and for their antibacterial response. Proteomics analyses revealed multiple pathways regulated by PP2A Cα, including mTORC1, PI3K/AKT, and Jak-STAT5. Abstract Although the functions of tyrosine phosphatases … Read more
CCAAT/enhancer‐binding protein α‐dependent regulation of granule formation in mast cells by intestinal bacteria. [[{“value”:”Ayaka Iketani, Mai Takano, Kazumi Kasakura, Miono Iwatsuki, Ayu Tsuji, Kou Matsuda, Remina Minegishi, Akira Hosono, Yusuke Nakanishi, Kyoko Takahashi”}]]
Specific gut microbes suppress granule formation in mast cells by inhibiting serglycin (SRGN) and mast cell protease 4 (Mcpt4) expression via reduced C/EBPα gene methylation, which leads to reduced histamine release. These mechanisms may play a part of antiallergic effects of gut microbiota. Abstract The antiallergic effects of gut microbiota have been attracting attention in … Read more
TGF‐β1 impairs IgA class switch recombination and production in porcine Peyer’s patches B cells. [[{“value”:”Caiying Wang, Yue Zhang, Yabin Lu, Xin Huang, Huazheng Jiang, Guohui Chen, Yongheng Shao, Huub F.J. Savelkoul, Christine A. Jansen, Guangliang Liu”}]]
By analyzing the downstream signaling pathways in IgM+ B cells isolated from porcine Peyer’s patches after exogenous TGF-β1 stimulation, we found that TGF-β1 reduces IgA CSR and production in pigs by inhibiting the phosphorylation of p38-MAPK, which may be related to the regulation of TGF-β1 on B-cell activation. Abstract Secretory IgA is crucial for preventing … Read more
Med1 controls thymic T‐cell migration into lymph node through enhancer‐based Foxo1‐Klf2 transcription program. [[{“value”:”Ning Yuan, Yanhong Su, Yang Gao, Biao Yang, Tianzhe Zhang, Qianhao Wang, Dan Zhang, Lin Shi, Anjun Jiao, Lei Lei, Lina Sun, Baojun Zhang”}]]
(1) Med1 deletion in T cells leads to impaired egress of thymic single-positive cells. (2) Med1 deletion impairs mature T cells’ ability to enter lymph nodes. (3) Med1 promotes Klf2 transcription through facilitating Foxo1 binding to the Klf2 enhancer. Abstract The migration is the key step for thymic T cells to enter circulation and then … Read more
Immune response to cold exposure: Role of γδ T cells and TLR2‐mediated inflammation. [[{“value”:”Daniel Vasek, Peter Holicek, Frantisek Galatik, Anna Kratochvilova, Bianka Porubska, Veronika Somova, Natalie Fikarova, Michaela Hajkova, Martin Prevorovsky, Jitka M Zurmanova, Magdalena Krulova”}]]
Our study investigates how short-term and long-term mild cold exposure in rats and regular cold swimmers influences immune response and thermogenesis, highlighting the crucial role of γδ T cells under physiological conditions and TLR2-mediated inflammation. These findings advance our understanding of the complex interactions between thermogenesis, neural signaling, and immune regulation. Abstract The mammalian body … Read more