Nature Reviews Immunology, Published online: 09 October 2026; doi:10.1038/s41577-026-01359-2This Review explores how the immune checkpoint receptor lymphocyte activation gene 3 (LAG3) suppresses T cell activity through newly defined si…
Nature Reviews Immunology, Published online: 09 October 2026; doi:10.1038/s41577-026-01366-3Metastasizing cancer cells release migrasomes containing tumour-specific antigens that can promote T cell responses.
Nature Reviews Immunology, Published online: 07 October 2026; doi:10.1038/s41577-026-01355-6Metabolic control is an integral component of B cell physiology, shaping fate decisions and effector functions, while also driving maladaptive …
Nature Reviews Immunology, Published online: 05 October 2026; doi:10.1038/s41577-026-01365-4A study in Nature by Cui et al. reports that sympathetic nerve activity during the growth phase of hair follicles activates endogenous retrovir…
Nature Reviews Immunology, Published online: 29 September 2026; doi:10.1038/s41577-026-01357-4In this Perspective, the authors use examples from evolution, animal models of disease and clinical results to explore how IFNγ, a quintessen…
Nature Reviews Immunology, Published online: 28 September 2026; doi:10.1038/s41577-026-01362-7A study in Immunity reports that protease allergens ‘train’ sensory neurons through metabolic remodelling to enhance the response to re-expos…
Nature Reviews Immunology, Published online: 28 September 2026; doi:10.1038/s41577-026-01358-3By exploring five enduring “negative spaces” in multiple sclerosis (MS) research, Kaufmann, Gold and Fugger challenge simple explanations of …
Nature Reviews Immunology, Published online: 28 September 2026; doi:10.1038/s41577-026-01361-8Immune-based therapies have transformed the treatment of cancer and inflammatory and autoimmune diseases, but treatment is often suboptimal a…
Nature Reviews Immunology, Published online: 25 September 2026; doi:10.1038/s41577-026-01353-8As Nature Reviews Immunology marks its twenty-fifth anniversary, leading immunologists reflect on the questions, challenges and conditions th…
Nature Reviews Immunology, Published online: 18 September 2026; doi:10.1038/s41577-026-01354-7Immune plasticity during the perinatal period enables mammalian offspring to successfully navigate the transition from prenatal, intrauterine…
