Lucy Bird Nature Reviews Immunology, Published online: 30 May 2025; doi:10.1038/s41577-025-01196-9A study describes how maternal immune activation can lead to neurodevelopmental deficits in offspring, through a mechanism involving granzyme B rel…
Nature Reviews Immunology, Published online: 28 April 2025; doi:10.1038/s41577-025-01180-3Microglia are not confined to the central nervous system but are also present in the periphery, wrapped around large neuronal somas of humans and…
Nature Reviews Immunology, Published online: 08 April 2025; doi:10.1038/s41577-025-01171-4A study shows that transient blockade of type I interferon signalling during T cell priming enhances the generation of stem cell-like memory CD8+…
Nature Reviews Immunology, Published online: 07 February 2025; doi:10.1038/s41577-025-01143-8To evade elimination by T cells, tumour cells transfer mutant mitochondria to T cells, which reprogrammes their metabolism and compromises the…
Nature Reviews Immunology, Published online: 02 January 2025; doi:10.1038/s41577-024-01127-0Stress-induced gut leakage and immune activation lead to the release of IL-22, which acts directly on septal neurons in the brain to dampen the…
Nature Reviews Immunology, Published online: 29 November 2024; doi:10.1038/s41577-024-01120-7Sialylated IgG protects against severe influenza by inducing the transcriptional repressor REST, which dampens the inflammatory response and p…
Nature Reviews Immunology, Published online: 11 October 2024; doi:10.1038/s41577-024-01101-wFebrile temperatures disrupt metabolism and induce DNA damage disproportionately in T helper 1 cell subsets. Cells that survive apoptosis and a…
Nature Reviews Immunology, Published online: 29 July 2024; doi:10.1038/s41577-024-01072-yTransient depletion of the gut microbiome by antibiotics in early life reduces systemic levels of the metabolite indole-3-propionic acid, which ca…
Nature Reviews Immunology, Published online: 12 July 2024; doi:10.1038/s41577-024-01065-xAge-associated defects in dendritic cells can be corrected by hyperactivating adjuvants containing an oxidized phospholipid to induce effective an…
Nature Reviews Immunology, Published online: 31 May 2024; doi:10.1038/s41577-024-01053-1CD8+ T cells become exhausted when exposed to the mechanical forces of stiff solid tumours, owing to signalling through the transcription factor OSR2.
