How does neural activity ignite skin inflammation? In this issue, Chen et al. show that one round of nociceptor activation builds a transient, chemokine CCL2-dependent dendritic cell-rich neighborhood, whereas a second round within the tested 3–12-h ra…
Inflammation can have lasting effects, but the mechanisms that drive these effects remain unclear. Adir and colleagues reveal that intestinal inflammation leaves a durable imprint in the extracellular matrix. This modified matrix redirects stem-cell fa…
The interferon-induced modification of cellular and viral proteins by ISG15 inhibits viral infection and is reversed by virus-encoded deISGylases, but the broad physiological impacts of this host-pathogen clash remain unclear. In this issue of Immunity…
The introduction of immune checkpoint blockade revolutionized cancer treatments. Since then, the field of immunotherapy has expanded exponentially, both in therapeutic innovations and applicable disease contexts. Investigators across disciplines discus…
Shared cancer driver mutations offer attractive targets for cancer immunotherapy, but their expression does not necessarily put them within the reach of a T cell response. In this issue of Immunity, Haratani et al. identify distinct barriers to the pro…
Astrocytes are glial cells important for neuronal health, but their functions in CNS immunopathology are less understood. In a recent issue of Nature, Lee et al. report that CD40 engagement and proinflammatory cytokines promote lipid droplet accumulati…
B cells can promote or restrain inflammation, yet harnessing their regulatory functions has been limited by a lack of understanding of how to efficiently induce them. In this issue of Immunity, Manfroi et al. identify chemical compounds that efficientl…
Interleukin (IL)-10 produced by B cells has regulatory functions in disease contexts. Manfroi et al. report a strategy for the efficient generation of IL-10-producing B cells using a chemical compound identified through a high-throughput screen. Upon t…
Messemaker et al. develop a TCR rapid assembly platform (T-RAP) and use it to generate a large high-quality dataset of functionally validated TCR-pMHC pairs. With the resulting validated TCR-pMHC dataset (TCRvdb), structure-based prediction of TCR-pMHC…
Menzel, Zhou, et al. examine the impact of surgical removal of tumor-draining lymph node (tdLN) resection on anti-tumor immunity. They find that after tdLN resection, tumor antigen is rerouted to distant LNs, where it supports tumor-specific T cell res…
