A Cell‐Intrinsic Role for RANK in Regulatory T Cells of the Human Thymus. [[{“value”:”Zoe‐Isabella Junginger, Ramona Adameck, Alexandre A. S. F. Raposo, Pedro Rosmaninho, Ana E. Sousa, Afonso R. M. Almeida”}]]

We identified RANK (TNFRSF11a) expression in human thymic FOXP3⁺ Tregs, revealing a previously unknown role for the RANK-RANKL axis in human tTreg development. We show that IL-2 and IL-15 can drive RANK expression in CD4⁺ tTregs, which in turn may modulate their maturation and proliferation within the thymic environment. Created in BioRender. Biorender, I. (2026) https://BioRender.com/gbrjlpa.