Mapping the immune microenvironment of KIT- and PDGFRA-mutant GISTs reveals genotype-specific immune infiltration and TKI-induced remodeling
BackgroundGIST tumor microenvironment is characterized by an abundant immune infiltrate. Imatinib exerts immunomodulatory effects that may contribute to a more immunosuppressive microenvironment. Nonetheless, checkpoint inhibitors have demonstrated lim…