Scientific problemStudying the acute, cell-intrinsic functions of signaling proteins in T cells has long been challenging. Existing constitutive or inducible gene deletion cannot overcome developmental adaptation that obscures true phenotypes. Similarl…
Macrophageexhibit remarkable functional plasticity and adopt M1-like pro-inflammatory or M2-like anti-inflammatory/pro-resolving states in response to microenvironmental stimuli. Notably, this binary functional classification originates largely from in…
BackgroundAdvanced triple-negative breast cancer (TNBC) has an extremely poor prognosis, and current therapies offer limited benefits for patients with low programmed cell death ligand 1(PD-L1) expression. This study innovatively proposes a “novel chem…
BackgroundAntigen-specific regulatory T-cell therapies seek to control donor-reactive immunity while preserving broader immune protection. The available platforms differ substantially in cellular composition, mode of antigen recognition, manufacturing …
BackgroundLangerhans cell histiocytosis (LCH) is a rare pediatric disease with marked clinical heterogeneity. Current risk stratification relies on the extent of organ involvement and risk-organ status, yet reliable protein biomarkers for distinguishin…
Neutrophil extracellular traps (NETs), long recognized as effectors of innate host defense, are now firmly implicated in remodeling the tumor microenvironment and facilitating tumor progression. Tumor-associated NETs expose proteases, damage-associated…
ObjectiveReliable biomarkers for early interstitial lung disease (ILD) risk stratification are limited; therefore, we aimed to identify prediagnostic proteins associated with incident ILD and develop a long-term prediction model.MethodsWe analyzed 52,7…
Colorectal anastomotic leakage is commonly framed as a technical complication or a consequence of intestinal dysbiosis. Neither view fully explains how a contaminated mucosal wound restores epithelial continuity while preserving a load-bearing submucos…
IntroductionType 1 diabetes (T1D) is an autoimmune disease characterized by progressive pancreatic β-cell destruction, yet molecular features distinguishing it from other autoimmune conditions in early life remain poorly defined. We previously identifi…
Brain-computer interfaces (BCIs) have made significant progress in fields such as neurorehabilitation, motor reconstruction, and alternative communication by capturing, decoding, and providing feedback on brain activity. In contrast, the application of…
