inmunoadmin J Leukoc Biol. 2026 May 18:qiag064. doi: 10.1093/jleuko/qiag064. Online ahead of print. ABSTRACT Eosinophils are increasingly recognized as tissue-resident immune cells that take on diverse functions. Recent studies have shed light on the pathways that result in tissue-specific eosinophil phenotypes. In this review, we discuss the process of tissue adaptation covering the local environmental cues … Read more
J Clin Immunol. 2026 May 19. doi: 10.1007/s10875-026-02026-w. Online ahead of print. ABSTRACT OBJECTIVE: To perform genetic diagnosis and pedigree analysis in a case of autosomal dominant Familial Behçet-like Autoinflammatory Syndrome type 3 (AIFBL3) caused by a novel RELA variant. METHODS: Peripheral blood samples collected from the proband and parents underwent conventional genetic screening, next-generation … Read more
Mucosal Immunol. 2026 May 16:100349. doi: 10.1016/j.mucimm.2026.100349. Online ahead of print. ABSTRACT Colonic immune homeostasis is critically maintained by regulatory T (Treg) cells. Here, we identify SUMO-specific peptidase 1 (SENP1) as an important regulator of colonic Treg function and intestinal immune homeostasis. Treg-specific Senp1 deletion does not impair thymic Treg development, but selectively disrupts the … Read more
Mucosal Immunol. 2026 May 16:100350. doi: 10.1016/j.mucimm.2026.100350. Online ahead of print. ABSTRACT Human enteric α-defensin 5 (HD5) is an antimicrobial peptide and a key effector of intestinal mucosal innate immunity. Paradoxically, HD5 has also been shown to enhance Shigella infection by inducing filopodial-like extensions via activation of the P2Y11 receptor. However, the broader physiological significance … Read more
Trends Immunol. 2026 May 16:S1471-4906(26)00101-8. doi: 10.1016/j.it.2026.04.008. Online ahead of print. ABSTRACT The adaptive immune system (AIS) is traditionally viewed as a defensive vertebrate innovation forged by pathogen pressure. Yet many of its core features suggest it is a homeostatic, regulatory circuit, not simply a sophisticated means of antimicrobial warfare. The horizontal transfer of mitochondria–endogenous … Read more
Curr Opin Immunol. 2026 May 15;101:102788. doi: 10.1016/j.coi.2026.102788. Online ahead of print. ABSTRACT The spleen is a central immune organ that surveys blood-borne pathogens and coordinates systemic immune responses. Within this organ, conventional dendritic cell (cDC) subsets occupy blood-exposed niches that enable efficient antigen capture and rapid initiation of T cell activation. While splenic cDC1s … Read more
Semin Immunol. 2026 May 15;82:102030. doi: 10.1016/j.smim.2026.102030. Online ahead of print. ABSTRACT Chagas disease, caused by Trypanosoma cruzi, remains one of the most striking examples of how parasite genetic diversity and host immune heterogeneity converge to shape chronic infection outcomes. This review integrates findings from studies across Latin America -Mexico and Central America, the Andean … Read more
Semin Immunol. 2026 May 15;82:102031. doi: 10.1016/j.smim.2026.102031. Online ahead of print. ABSTRACT The interleukin-1 (IL-1) superfamily encompasses a group of cytokines with central roles in inflammation and immune regulation. IL-1 is directly implicated in activating survival and proliferative pathways in transformed cells, orchestrating the angiogenic switch, remodeling the extracellular matrix, and driving invasion and metastatic … Read more
Cancer Immunol Res. 2026 May 15. doi: 10.1158/2326-6066.CIR-25-1490. Online ahead of print. ABSTRACT Chimeric antigen receptor (CAR) T-cell therapy has shown remarkable efficacy in hematologic malignancies but remains limited in solid tumors because of the immunosuppressive microenvironment, tumor heterogeneity, poor immune-cell infiltration, and progressive T-cell dysfunction. Because cytokine costimulation is critical for maintaining T-cell fitness, … Read more
J Immunol. 2026 May 14;215(5):vkag070. doi: 10.1093/jimmun/vkag070. ABSTRACT During the response to infections and pathogenic challenges, T cells must expand profoundly and be resilient to repetitive restimulation to clear the ongoing assault and protect the host. This process of prolific expansion is tightly regulated to quickly provide a robust pool of pathogen-fighting T cells, yet … Read more
