inmunoadmin

Ets1 represses Blimp1 to promote germinal center T follicular helper cell differentiation during viral infection

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J Immunol. 2026 May 14;215(5):vkag096. doi: 10.1093/jimmun/vkag096. ABSTRACT Following acute viral infection, naïve CD4+ T cells differentiate into T helper 1 (Th1) and T follicular helper (Tfh) cells. The transcription factor Ets1 represses Tfh cell formation and function following protein immunization; however, whether Ets1 regulates Tfh differentiation in viral infection is unclear. Here, we demonstrate … Read more

Factor H-Related Protein 1 Deficiency and Risk of Severe Falciparum Malaria in Ghanaian Children: A Cohort Analysis​Alliyah Uhmon Byrd on 14 de May de 2026 at 10:00

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J Leukoc Biol. 2026 May 14:qiag063. doi: 10.1093/jleuko/qiag063. Online ahead of print. ABSTRACT Malaria caused by Plasmodium falciparum remains a leading cause of childhood mortality in sub-Saharan Africa. The intraerythrocytic parasite can evade complement-mediated destruction through recruitment of human Factor H (FH). In vitro, Factor H-Related Protein 1 (FHR-1) competes with FH for binding sites, … Read more

Can we cure primary biliary cholangitis?

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Curr Opin Immunol. 2026 May 14;100:102786. doi: 10.1016/j.coi.2026.102786. Online ahead of print. ABSTRACT Primary biliary cholangitis (PBC) is a chronic immune-mediated liver disease characterized by progressive destruction of the intrahepatic bile ducts, leading to cholestasis, fibrosis, and eventual cirrhosis. Despite advances in understanding disease pathogenesis, treatment pathways are focused on maintenance rather than cure. Moreover, … Read more

Won’t you be my neighbor? Control of the immune response by stromal and immune cell microenvironments within the lymph node

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Curr Opin Immunol. 2026 May 13;100:102787. doi: 10.1016/j.coi.2026.102787. Online ahead of print. ABSTRACT Efficacious immune responses require the coordinated encounter of rare antigen-specific adaptive lymphocytes with their cognate innate antigen-presenting cells (APCs) in space and time. This spatiotemporal problem of immunity is solved by secondary lymphoid organs, such as lymph nodes (LNs), which coordinate adaptive … Read more

Gut-derived, inflammatory ILC2s disseminate type 2 immunity to remote lung in food allergen-challenged mice​Natalie A Falta on 14 de May de 2026 at 10:00

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J Leukoc Biol. 2026 May 14:qiag056. doi: 10.1093/jleuko/qiag056. Online ahead of print. ABSTRACT Dissemination of type 2 immunity along skin-gut-lung axes contributes to allergic march progressions in atopic individuals, yet the underlying mechanisms remain incompletely understood. In mice, gastrointestinal helminth infections can mobilize a circulating pool of gut-derived, inflammatory type 2 innate lymphoid cells (iILC2s), … Read more

Combined cyclosporine A and urolithin A therapy ameliorates murine lupus nephritis

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J Immunol. 2026 Apr 15;215(4):vkag087. doi: 10.1093/jimmun/vkag087. ABSTRACT Monotherapies for lupus nephritis (LN) often fail to fully control the disease’s hallmark, renal inflammation and immune complex deposition. This study investigates a novel combination therapeutic strategy using urolithin A (UA), a multifaceted anti-inflammatory and antioxidant agent, with cyclosporine A (CsA), an established immunosuppressant. The combination therapy’s … Read more

Sustained Effector Functions and Memory Accumulation of αβ T Cells in Children With Congenital Heart Disease. [[{“value”:”Yusuf Eshimutu Abu, Christoph Kammeyer, Tao Yang, Rodrigo Gutierrez Jauregui, Alexa Cramer, Claudia Junge, Svea Kleiner, Anika Janssen, Adan Chari Jirmo, Alexander Horke, Reinhold Förster, Philipp Beerbaum, Martin Boehne, Sarina Ravens”}]]

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This study showed dysregulated αβ T cell homeostasis with ongoing T cell activation and low-grade inflammation in 5-12-year-old CHD children who underwent early-life cardiac surgery with thymectomy, characterized by reduced naïve T cells and increased memory/effector and senescent-like T cells. There was also higher expression of inhibitory receptors on effector T cells and elevated suppressive … Read more

Integrating Genetics and Environment to Find Causal Mechanisms for Multiple Sclerosis. [[{“value”:”Alicia Munoz Leon, Matthew R. Lincoln”}]]

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Genetic and epidemiological studies have together identified hundreds of risk factors for MS, but we know relatively little about the mechanisms through which these cause disease. In this review, we explore a new generation of studies that are integrating genetics and environment to uncover disease mechanisms. Progress toward novel therapeutics is likely to come from … Read more

Hypoxia-induced ADAM8⁺ macrophages and FAP⁺ fibroblasts form an extracellular matrix-remodeling niche at the tumor boundary in HCC

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Cancer Immunol Res. 2026 May 13. doi: 10.1158/2326-6066.CIR-25-1240. Online ahead of print. ABSTRACT In hepatocellular carcinoma (HCC), stromal and immune components shape invasion and metastasis. To identify the cellular states that drive extracellular matrix (ECM) remodeling, define their organization at the tumor margin, and evaluate their association with prognosis, we profiled stromal regions at the … Read more

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