Trends in Immunology

Trends Immunol. 2026 Sep 16:S1471-4906(26)00230-9. doi: 10.1016/j.it.2026.08.014. Online ahead of print. ABSTRACT The immune system balances protective immunity against pathogens with tolerance to self and selected foreign antigens. Emerging evidence identifies erythropoietin (EPO) as a systemic immunoregulatory signal that links physiological stress to immune adaptation. Beyond its canonical role in erythropoiesis, EPO-EPO receptor (EPOR) signaling … Read more

Trends Immunol. 2026 Sep 16:S1471-4906(26)00229-2. doi: 10.1016/j.it.2026.08.013. Online ahead of print. ABSTRACT Dendritic cells (DCs) are professional orchestrators of the immune system, integrating environmental signals to initiate, modulate, and sustain antitumor immunity. Although their therapeutic potential extends beyond antigen delivery, most clinical strategies have used DCs primarily as cellular vaccines. Here, we propose that DCs … Read more

Trends Immunol. 2026 Sep 14:S1471-4906(26)00228-0. doi: 10.1016/j.it.2026.08.012. Online ahead of print. ABSTRACT Natural killer (NK) cell immunotherapies remain less effective in solid tumors than in hematologic malignancies. Poor infiltration, checkpoint engagement, and metabolic stress contribute, but these mechanisms often operate within spatially organized niches. We develop the concept of spatially instructed checkpoints: inhibitory programs locally … Read more

Trends Immunol. 2026 Sep 9:S1471-4906(26)00227-9. doi: 10.1016/j.it.2026.08.011. Online ahead of print. ABSTRACT Clinical immunology is increasingly recognizing diet not merely as baseline metabolic sustenance but as a tunable pharmacological tool. By targeting conserved nutrient-sensing networks and the microbiome, defined nutritional protocols-such as fasting mimetics and specific macronutrient titrations-can actively rewire immune responses. In this review, … Read more

Trends Immunol. 2026 Sep 7:S1471-4906(26)00223-1. doi: 10.1016/j.it.2026.08.007. Online ahead of print. NO ABSTRACT PMID:42705942 | DOI:10.1016/j.it.2026.08.007

Trends Immunol. 2026 Sep 7:S1471-4906(26)00216-4. doi: 10.1016/j.it.2026.08.003. Online ahead of print. ABSTRACT Certain human leukocyte antigen (HLA) alleles occur more often in people with immune-mediated inflammatory diseases (IMIDs) than in unaffected individuals, making HLA one of the strongest inherited contributors to IMID risk. Yet how these alleles promote disease remains unclear. We argue that HLA … Read more

Trends Immunol. 2026 Sep 7:S1471-4906(26)00224-3. doi: 10.1016/j.it.2026.08.008. Online ahead of print. NO ABSTRACT PMID:42705940 | DOI:10.1016/j.it.2026.08.008

Trends Immunol. 2026 Sep 7:S1471-4906(26)00225-5. doi: 10.1016/j.it.2026.08.009. Online ahead of print. NO ABSTRACT PMID:42705939 | DOI:10.1016/j.it.2026.08.009

Trends Immunol. 2026 Sep 1:S1471-4906(26)00220-6. doi: 10.1016/j.it.2026.08.004. Online ahead of print. ABSTRACT Multiple myeloma remains incurable despite therapeutic advances. Longitudinal profiling of bone marrow and peripheral blood by Chander et al. reveals selective persistence of malignant plasma cell states, compartment-specific immune remodeling, incomplete humoral recovery after autologous stem cell transplantation, and divergent vaccine responses. PMID:42680673 … Read more

Trends Immunol. 2026 Aug 28:S1471-4906(26)00189-4. doi: 10.1016/j.it.2026.07.010. Online ahead of print. ABSTRACT Metastasis is an inefficient cellular process in which most disseminated tumor cells fail to form secondary lesions in distant tissues due to hostile conditions, such as protective immune surveillance. The few cells that survive these threats can seed subclinical metastatic lesions, known as … Read more