inmunoadmin

Papaverine ameliorates psoriasis-like skin inflammation by regulating immune cell differentiation and RAGE-S100A7 axis in an imiquimod-induced murine model

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J Immunol. 2026 Aug 29;215(9):vkag233. doi: 10.1093/jimmun/vkag233. ABSTRACT Psoriasis is a chronic, immune-mediated inflammatory skin disease affecting at least 2% of the global population. Papaverine, an alkaloid with known anti-inflammatory, anti-cancer, and RAGE-antagonistic properties, has not been previously evaluated for anti-psoriatic activity. This study investigated the protective effects and mechanisms of papaverine in an imiquimod … Read more

Selenium serves as an immunomodulator adjunct to enhance the efficacy of anti-PD-1 therapy in non-small cell lung cancer

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J Immunol. 2026 Aug 29;215(9):vkag241. doi: 10.1093/jimmun/vkag241. ABSTRACT The role of selenium in tumor progression remains controversial, and its mechanisms of action in the context of immunotherapy are poorly understood. In this study, our findings indicate that selenium supplementation did not alter immune parameters, induce organ damage under healthy conditions, or affect the growth of … Read more

Power to the Tregs in transplantation tolerance in LATAM: From the basics to the bedside. Karina Pino-Lagos

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Semin Immunol. 2026 Sep 11;84:102066. doi: 10.1016/j.smim.2026.102066. Online ahead of print. ABSTRACT T regulatory cells (Tregs) come in different flavors, but they all share suppressive function and the role in the generation and maintenance of immune tolerance. Due to this essential activity, Tregs are targets for immunotherapy: Tregs promotion is wanted in pathological conditions such … Read more

KRAS-G12C inhibition-induced enrichment of MHC-Ihigh immune-active tumor cells directs immune-effector TME development to augment therapeutic efficacy

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Cancer Immunol Res. 2026 Sep 11. doi: 10.1158/2326-6066.CIR-26-0213. Online ahead of print. ABSTRACT Inhibition of KRASG12C (G12Ci) has shown promising clinical activity in several cancers; however, emergence of resistance is a major limitation to long-term benefit. It remains unknown how G12Ci impacts the tumor immune microenvironment and its association with resistance. We investigated the immune … Read more

Phenotypic and functional characterization of tumor-reactive T cells in malignant pleural effusions

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Cancer Immunol Res. 2026 Sep 11. doi: 10.1158/2326-6066.CIR-26-0293. Online ahead of print. ABSTRACT Adoptive cell therapy using tumor-infiltrating lymphocytes (TIL) is effective for treating advanced melanoma but requires surgical tumor resection. Malignant pleural effusions (MPE) may provide a more accessible source of tumor-reactive T cells. Synchronously collected MPE, lung metastasis, and blood from a patient … Read more

Spatial statistics infer structured immune signatures in primary prostate cancer

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Cancer Immunol Res. 2026 Sep 11. doi: 10.1158/2326-6066.CIR-26-0106. Online ahead of print. ABSTRACT The spatial arrangement of immune cells in the tumor microenvironment (TME) varies widely, from dispersed to clustered and tumor excluded to infiltrating. Multiplexed spatial profiling is an effective means of characterizing tumor-infiltrating lymphocytes (TILs) and immune complexes such as tertiary lymphoid structures … Read more

The C‐Type Lectin Mincle Serves as a Pattern Recognition Receptor for the Lipid Envelope of Human Cytomegalovirus. [[{“value”:”Vladimir Bokun, Wengang Chai, Robert Buchanan, Elliot Murphy, Yan Liu, Beth Holder, Alexiane Decout”}]]

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Whether viral lipids can directly interact with pattern recognition receptors to modulate antiviral immune responses remains unclear. We show that Mincle-dependent recognition of HCMV viral particles induces proinflammatory cytokine production in primary human macrophages. These findings demonstrate that Mincle recognition of HCMV lipid envelope constitutes a novel pattern recognition mechanism. ABSTRACT Enveloped viruses possess a … Read more

A systematic review of juvenile dermatomyositis complicated by macrophage activation syndrome

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Curr Opin Immunol. 2026 Sep 10;103:102834. doi: 10.1016/j.coi.2026.102834. Online ahead of print. ABSTRACT BACKGROUND: Macrophage activation syndrome (MAS) is a rare but potentially life-threatening complication of juvenile dermatomyositis (JDM). Data on its clinical presentation, diagnosis, treatment, and outcomes remain limited. OBJECTIVE: To systematically review the literature on MAS occurring in patients with JDM. METHODS: A … Read more

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