inmunoadmin

This study integrates immunohistochemical evidence of NK cell infiltration in solid tumors, clinical outcomes of NK cell-based therapies, and transcriptomic analyses of more than 10,000 TCGA samples. Together, these complementary datasets provide a multimodal framework for prioritizing tumor indications and informing the rational design of future NK cell-based clinical trials. ABSTRACT T cell-based immunotherapies have … Read more

Intranasal vaccination induces pulmonary neutrophil accumulation and SLPI release, accompanied by changes in soluble mediators associated with tissue remodelling, coagulation, and total IgA. ABSTRACT Vaccines delivered via the nasal route have attracted increasing attention for their capacity to engage the mucosal immune system at the primary site of pathogen entry. However, the early innate mechanisms … Read more

SARS-CoV-2 infection drives transient B-cell remodeling toward an activated, regulatory-like phenotype. In this randomized sub-study, the polyclonal neutralizing antibody XAV-19 did not detectably alter B-cell phenotype, transcriptome, or function relative to placebo, indicating that passive polyclonal therapy preserves B-cell homeostasis during acute COVID-19. ABSTRACT Regulatory B cells (Bregs) are emerging as pivotal modulators of immune … Read more