Disruption of ACTG1 potentiates anti-TIM-3 immunotherapy by reprogramming the immunosuppressive microenvironment via the CSF3/CSF3R axis in pancreatic cancer
BackgroundThe limited immune infiltration observed in pancreatic ductal adenocarcinoma (PDAC) is a major factor contributing to immunotherapy resistance and the consistently poor prognosis. Hence, identifying novel therapeutic targets and developing ef…