T cell Cyp27b1 promotes granzyme B expression and antiviral host defense in a mouse model of H1N1 influenza A virus infection
IntroductionImmune cells express vitamin D receptors (VDR) and the CYP27B1 enzyme needed to produce the VDR ligand, 1,25(OH)2D; suggesting that perhaps the vitamin D response is regulated locally at the site of infection. Here, we examined the role of …