Tumor-educated macrophages promote ferroptosis inhibition in pancreatic cancer via activating the p62-KEAP1-NRF2 pathway
BackgroundPancreatic cancer is one of the most aggressive and lethal gastrointestinal malignancies, and ferroptosis resistance contributes to chemoresistance. Tumor-educated macrophages(TAMs) are key components of the tumor microenvironment, but whethe…