TCR clonotyping of paired blood and tonsillar T-follicular cells reveals the mixed origin of CD38high Tfrs
Circulating T follicular regulatory (cTfr) cells are measured as blood biomarkers after vaccination, in autoimmune disease (e.g., lupus, rheumatoid arthritis) and cancer immunotherapy, yet whether they originate from natural Tregs (yielding nTfr) or ge…