SPOCK2-mediated phenotype switch of vascular smooth muscle cells contributes to aortic aneurysm in Kawasaki disease

BackgroundCoronary artery aneurysm is a major cardiovascular complication of Kawasaki disease (KD). The phenotype switch of vascular smooth muscle cells (VSMCs) plays a crucial role in pathological vascular wall remodeling in KD; however, the molecular…

CAR-T cell therapies in autoimmune rheumatic diseases: a brief report on the clinical trial landscape, current status, and future perspectives

Autoimmune rheumatic diseases (ARDs) are chronic inflammatory disorders where B cells play a key role. Traditional B-cell-targeted therapies have limitations, whereas CAR-T-cell therapy, which aims for a broader reset of the B-cell compartment by targe…

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