Yan Wu

Glioma remains largely refractory to immune-checkpoint blockade, in part because tumor-intrinsic mechanisms sustain programmed death-ligand 1 (PD-L1) and reinforce an immunosuppressive microenvironment. Tripartite motif-containing 14 (TRIM14) is an imm…

BackgroundMultiple sclerosis (MS) is a chronic neuroinflammatory disorder characterized by demyelination and immune dysregulation, and microglia play a central role in disease progression. Despite this, the specific microglial gene signatures contribut…