Single-cell and spatial multi-omics combined with machine learning to unravel the heterogeneity of cholangiocarcinoma and the WFDC3-mediated prognostic regulatory mechanisms
BackgroundIntrahepatic cholangiocarcinoma (ICC) exhibits substantial cellular heterogeneity and a complex tumor microenvironment (TME), contributing to poor clinical outcomes. Effective prognostic biomarkers and a deeper understanding of the cellular e…