Anti-gamma-aminobutyric acid type B receptor (anti-GABA-B receptor) encephalitis is a rare autoimmune limbic encephalitis that frequently presents with seizures and may be associated with malignancy, most commonly small-cell lung cancer. We report a 66…
BackgroundTo report a refractory Takayasu arteritis (TAK) patient who developed a severe inflammatory flare after tocilizumab (TCZ) therapy and explore the underlying mechanism.Case presentationA 21-year-old female with active TAK received TCZ after in…
BackgroundIvonescimab is a PD-1/VEGF bispecific antibody that combines immune checkpoint blockade with anti-angiogenic activity. As PD-1/VEGF-directed regimens enter routine solid-tumor care, rare toxicities at the interface of immune activation, endot…
BackgroundDrug reaction with eosinophilia and systemic symptoms (DRESS) is a potentially fatal adverse drug reaction featuring widespread eruption, fever, and multi-organ involvement. Carbamazepine is a leading causative agent in Asian populations. Whi…
Atopic dermatitis (AD) is a chronic, relapsing inflammatory skin disorder characterized by intense pruritus, eczematous lesions, and significant impairment of quality of life. In severe or chronic cases, AD can present with diverse atypical phenotypes,…
Currently, CAR-T cell therapy bridging to allogeneic hematopoietic stem cell transplantation (allo-HSCT) has become a pivotal therapeutic strategy for refractory/relapsed hematologic malignancies. Sequential therapy with CD7 chimeric antigen receptor T…
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an aggressive hematologic malignancy with limited therapeutic options for patients ineligible for allogeneic hematopoietic stem cell transplantation (allo-HSCT). While CD123-targeted therapies and…
Immunoglobulin light chain (AL) amyloidosis and POEMS syndrome are plasma cell proliferative disorders involving multiple organs and tissues, often presenting with nonspecific clinical manifestations. The co-occurrence of both conditions in a single pa…
BackgroundFocal segmental glomerulosclerosis (FSGS) is a heterogeneous glomerular disease frequently treated with high-dose glucocorticoids and calcineurin inhibitors, which can markedly increase susceptibility to opportunistic infections.Case presenta…
IntroductionDiGeorge syndrome (DGS) is an inborn error of immunity characterized by wide phenotypic variability, with a broad spectrum of autoimmune manifestations, including autoimmune cytopenias, thyroiditis, and juvenile idiopathic arthritis (JIA). …
