Case Report: From chronic infection to disseminated strongyloidiasis: a case of corticosteroid-induced hyperinfection syndrome

BackgroundStrongyloides stercoralis (S. stercoralis) is a soil-transmitted nematode predominantly endemic to tropical and subtropical regions, capable of causing life-threatening hyperinfection syndrome and disseminated infection in immunocompromised i…

Case Report: Benralizumab-induced remission in adolescent-onset ANCA-positive eosinophilic granulomatosis with polyangiitis

Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis characterized by asthma, eosinophilia, and multi-organ involvement. Adolescent-onset disease is uncommon, and evidence guidi…

Case Report: Immune checkpoint inhibitor-induced IgG4-related disease mimicking renal metastatic progression: successful steroid-sparing management with rituximab

BackgroundImmune checkpoint inhibitors (ICIs) can induce a broad spectrum of immune-related adverse events (irAEs), including rare fibroinflammatory autoimmune manifestations. IgG4-related disease (IgG4-RD) has only exceptionally been described followi…

Efgartigimod in the treatment of immune checkpoint inhibitor-related myasthenia gravis -myositis overlap syndrome: a case report

BackgroundA subset of cancer patients receiving monoclonal antibody PD-1/PD-L1 inhibitors may develop immune checkpoint inhibitor (ICI)-related neurological complications, such as ICI-related myasthenia gravis(MG)-myositis overlap syndrome and ICI-rela…

Non-bacterial cystitis following treatment with toripalimab for alpha-fetoprotein-producing gastric adenocarcinoma: a case report

Immune checkpoint inhibitors (ICIs) have revolutionized the management of gastric cancer; however, they can lead to rare immune-related adverse events (irAEs) affecting the urinary system. Herein, we report a case of non-bacterial cystitis complicated …

Combination therapy with anti-PD-1 antibody, radiotherapy, and tyrosine kinase inhibitor for unresectable primary ectopic hepatocellular carcinoma: a case report with genomic profiling and literature review

BackgroundEctopic hepatocellular carcinoma (EHCC) is an exceedingly rare malignancy characterized by its occurrence outside the liver without a detectable intrahepatic primary tumor. Owing to its rarity and the absence of standardized management guidel…

Case Report: Successful telitacicept treatment for IgA nephropathy with stage 4 chronic kidney disease and acute renal failure

Immunoglobulin A nephropathy (IgAN) is one of the most common forms of primary glomerulonephritis and can lead to renal failure requiring renal replacement therapy via dialysis. Current research indicates that telitacicept, an APRIL and BAFF inhibitor,…

Case Report: Hemophagocytic lymphohistiocytosis secondary to Escherichia coli infiltration of bone marrow in a patient with seronegative rheumatoid arthritis treated with low-dose methotrexate

Hemophagocytic lymphohistiocytosis (HLH) is a disorder characterized by dysregulated immune activation triggered by various etiologies, leading to excessive inflammatory responses, cytokine storm, and subsequent organ dysfunction. While the presence of…

Case Report: AQP4-IgG-positive neuromyelitis optica spectrum disorder with CSF anti- NMDAR1 IgG positivity and encephalitic features

BackgroundOverlap between aquaporin-4 immunoglobulin G (AQP4-IgG)-positive neuromyelitis optica spectrum disorder (NMOSD) and anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is uncommon and may be difficult to recognize, especially when NMOSD i…

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