BackgroundReactive cutaneous capillary endothelial proliferation (RCCEP) is a characteristic cutaneous adverse event associated with immune checkpoint inhibitors. This study compared two prophylactic thalidomide doses to identify the more promising dos…
ObjectiveThis study aimed to investigate the impact of vunakizumab on adverse events (AEs) in patients with moderate-to-severe plaque psoriasis.MethodsThis exploratory post-hoc analysis used data from a phase III trial (NCT04839016). A total of 690 pat…
BackgroundLiver depression syndrome (LDS) is a core Chinese medicine (CM) syndrome implicated in the onset and progression of breast cancer, whose molecular mechanisms remain poorly understood, hindering further investigation.MethodsWe prospectively en…
ObjectiveTo evaluate the immunogenicity of a tetanus vaccine, adsorbed (TTVA) in people aged 18 years and above.MethodsA randomized, double-blinded, and positive controlled clinical trial was conducted in Bijie, Guizhou Province, China. Participants ag…
ObjectivePD-1 based immunochemotherapy has improved bladder cancer (BC) outcomes, yet individual responses remain heterogeneous. Low-cost, non-invasive predictive biomarkers are urgently needed. Urinary protein semi-quantification (UPSQ) correlates wit…
IntroductionVaccines targeting avian influenza virus A/H7N9 are poorly immunogenic. While the immune responses can be improved with oil-in-water emulsion adjuvants such as Adjuvant System 03 (AS03), the cellular mechanisms underpinning the adjuvant eff…
BackgroundSystemic administration of immunotherapy via intravenous injection is frequently associated with off-target toxicity throughout the body. In contrast, intratumoral injection has emerged as a promising strategy to mitigate systemic adverse eff…
BackgroundPostoperative lymph node recurrence in esophageal squamous cell carcinoma (ESCC) is associated with poor prognosis and lacks standardized treatment. Radioresistance and aberrant immune/inflammatory tumor microenvironment (TME) are major barri…
This study aimed to evaluate the safety and immunogenicity of a novel diphtheria, tetanus, and pertussis (acellular, three components) combined vaccine, adsorbed (DTcP) vaccine compared to the existing co-purified DTaP vaccine in China. In this partial…
BackgroundThe mobilization of peripheral blood stem cells(PBSC) needs daily injection of granulocyte colony stimulating factor (G-CSF), which brings inconvenience to healthy donors. Can pegylated granulocyte colony-stimulating factor (Peg-G-CSF) solve …
