Immunity

(Immunity 56, 1910–1926.e1–e7; August 8, 2023)

Mutations in TP53 occur early in malignant transformation and are generally present in all descendant tumor cells. Haratani et al. find a dearth of actionable neoantigens displayed in the cancer immunopeptidome and define various mechanisms whereby tum…

(Immunity 59, 1–21.e1–e7; March 10, 2026)

Antigenic and environmental stimuli sensed by innate and adaptive immune cells trigger cognate functions that allow the coordination of the appropriate immune response. In this issue of Immunity, Tzerpos et al. and Jay et al. demonstrate that chromatin…

Accumulating evidence implicates sensory neurons in tumor progression, but signals linking nociceptive activity to impaired antitumor immunity remain unclear. In a recent issue of Cell, Ho et al. show that nociceptor activation impedes TLS assembly thr…

Candida albicans induces Th17 cells, but their origins remain unresolved. In this issue of Immunity, Martini et al. show that the mouth is a reservoir for fungal Th17 cells that adopt pathogenic signatures in the gut during Crohn’s disease.

The unprecedented recent advancement in the field of interoception (sensing self) has introduced neuromodulation as a realistic treatment approach. Shibuya et al. identified an ear-to-lung reflex in which activation of auricular-innervating TRPV1+ vaga…

(Immunity 59, 2500–2514.e1–e8; September 8, 2026)

Autoantibodies (autoAbs) are linked to mortality and Long COVID, yet their cellular origins remain unclear. Yuan et al. identify a distinct B cell population (DN2 cells) as a key source of autoAbs during SARS-CoV-2 infection. These cells mirror lupus D…

Sepsis lacks effective therapeutic interventions. Fish et al. examine sepsis patients and identify three temporal immune states with distinct resistance, disease tolerance, and resilience program trajectories. Early and late immune responses do not ali…